Patient-Level Disease Burden as a Predictor of In-Field Failures in Patients Undergoing Bridging Radiotherapy for CD19-Directed Chimeric Antigen Receptor (CAR) T-Cell Therapy for Recurrent/Refractory Large B-Cell Lymphomas
Figura N, Sim A, Chavez J, Shah B, Khimani F, Lazaryan A, Davila M, Bachmeier C, Nishihori T, Liu H, Christopherson K, Kim S, Locke F, Jain M, Robinson T. Patient-Level Disease Burden as a Predictor of In-Field Failures in Patients Undergoing Bridging Radiotherapy for CD19-Directed Chimeric Antigen Receptor (CAR) T-Cell Therapy for Recurrent/Refractory Large B-Cell Lymphomas. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: s85. DOI: 10.1016/j.ijrobp.2022.07.491.Peer-Reviewed Original ResearchMedian metabolic tumor volumeT-cell therapyRefractory large B-cell lymphomaCAR T-cell therapyLarge B-cell lymphomaBRT patientsDisease burdenTotal disease burdenB-cell lymphomaField progressionRadiation therapyLocal controlClinical outcomesExact testChimeric antigen receptor T-cell therapyCAR T-cell infusionDistant-only failureDurable local controlLocal-only failureWorse disease burdenFuture prospective trialsT-cell infusionHigh-risk patientsKaplan-Meier methodLow disease burdenOral Mucosal Sparing in High-Dose Total Body Irradiation (TBI) prior to Stem Cell Transplantation (SCT) for Acute Leukemia
Liveringhouse C, Sandoval M, Dohm A, Weygand J, Garcia G, Peters J, Nieder M, Faramand R, Jain M, Locke F, Bejanyan N, Kim S, Robinson T, Latifi K. Oral Mucosal Sparing in High-Dose Total Body Irradiation (TBI) prior to Stem Cell Transplantation (SCT) for Acute Leukemia. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: e353. DOI: 10.1016/j.ijrobp.2022.07.1462.Peer-Reviewed Original ResearchNon-relapse mortalityTotal body irradiationStem cell transplantationHigh-grade oral mucositisPlanning target volumeOral mucositisAcute oral mucositisAcute lymphocytic leukemiaAcute leukemiaMucosal sparingOral mucosaExact testRisk of NRMHigh-dose total body irradiationDose total body irradiationHost disease (GVHD) prophylaxisResults 25 patientsMedian patient ageSevere oral mucositisFatal respiratory failureFisher's exact testNon-significant trendIMRT/VMATConditioning chemotherapyFatal GVHD