2021
A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis
Ghanbarpour A, Valverde DP, Melia TJ, Reinisch KM. A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2101562118. PMID: 33850023, PMCID: PMC8072408, DOI: 10.1073/pnas.2101562118.Peer-Reviewed Original ResearchConceptsLipid transfer proteinEndoplasmic reticulumAutophagy protein ATG2Membrane dynamics processesTransfer proteinOrganelle biogenesisAutophagosome biogenesisCytosolic leafletOrganelle membranesMembrane expansionScramblasesVMP1Lipid homeostasisTMEM41BAtg9BiogenesisBulk lipidsProteinLipidsAtg2GolgiOrganellesReticulumLeafletsHomeostasis
2007
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
Shen J, Tareste DC, Paumet F, Rothman JE, Melia TJ. Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins. Cell 2007, 128: 183-195. PMID: 17218264, DOI: 10.1016/j.cell.2006.12.016.Peer-Reviewed Original ResearchConceptsSec1/Munc18 (SM) proteinsMunc18 proteinsSm proteinsIntracellular membrane fusionSNARE fusion machineryCognate SNAREsV-SNAREFusion specificityFusion machineryMunc18-1Membrane fusionMolecular mechanismsStimulatory subunitProteinNeurotransmitter releaseFundamental roleSNAREpinsSelective activationExocytosisSubunitsMachinerySnareFusionActivationBilayers