Lithium reduces impulsive decision making in transdiagnostic patients at high risk for suicide attempt recurrence: A randomized, double blind, placebo-controlled, crossover study
Murphy N, Pham G, Weyland A, Engelhardt J, Kypriotakis G, Thomas Y, Kosten T, Moukaddam N, Mathew S, Swann A. Lithium reduces impulsive decision making in transdiagnostic patients at high risk for suicide attempt recurrence: A randomized, double blind, placebo-controlled, crossover study. Journal Of Affective Disorders Reports 2024, 17: 100833. DOI: 10.1016/j.jadr.2024.100833.Peer-Reviewed Original ResearchImmediate memory taskInternal State ScaleTime perception tasksSuicidal behaviorImpulsive decisionsSuicide attemptsResponse latencySpectrum of suicidal behaviorsLethal suicidal behaviorMeasures of impulsivityLithium doseConservative response biasSevere suicide attemptsDouble-blind crossover designRandomized double-blind crossover designPrevent suicide riskEffects of lithiumPill placeboMemory taskBehavioral therapySuicide riskResponse biasAdjunctive behavioral therapySelf-harmAssociated with attemptsVal/Met BDNF as a genetic risk for a false sense of security in post-discharge suicide risk
Rufino K, Goli P, Patriquin M, Kosten T, Nielsen D, Salas R. Val/Met BDNF as a genetic risk for a false sense of security in post-discharge suicide risk. Journal Of Affective Disorders 2024, 354: 98-103. PMID: 38447916, DOI: 10.1016/j.jad.2024.03.001.Peer-Reviewed Original ResearchSuicide riskAssociated with suicide riskHigher risk of suicide attemptRisk of suicide attemptSuicidal ideation levelsMet variantSuicidal ideation scoresHigh riskPost-discharge suicidesPsychiatric inpatient carePost-discharge periodPsychiatric inpatientsIdeation scoresSuicidal ideationSuicide attemptsInpatient treatmentNo significant associationAssociated with such riskInpatient careDiverse sampleSuicideBDNFIdeational levelGenetic riskInpatients