Lithium reduces impulsive decision making in transdiagnostic patients at high risk for suicide attempt recurrence: A randomized, double blind, placebo-controlled, crossover study
Murphy N, Pham G, Weyland A, Engelhardt J, Kypriotakis G, Thomas Y, Kosten T, Moukaddam N, Mathew S, Swann A. Lithium reduces impulsive decision making in transdiagnostic patients at high risk for suicide attempt recurrence: A randomized, double blind, placebo-controlled, crossover study. Journal Of Affective Disorders Reports 2024, 17: 100833. DOI: 10.1016/j.jadr.2024.100833.Peer-Reviewed Original ResearchImmediate memory taskInternal State ScaleTime perception tasksSuicidal behaviorImpulsive decisionsSuicide attemptsResponse latencySpectrum of suicidal behaviorsLethal suicidal behaviorMeasures of impulsivityLithium doseConservative response biasSevere suicide attemptsDouble-blind crossover designRandomized double-blind crossover designPrevent suicide riskEffects of lithiumPill placeboMemory taskBehavioral therapySuicide riskResponse biasAdjunctive behavioral therapySelf-harmAssociated with attemptsCorrelates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder
Bigdeli T, Barr P, Rajeevan N, Graham D, Li Y, Meyers J, Gorman B, Peterson R, Sayward F, Radhakrishnan K, Natarajan S, Nielsen D, Wilkinson A, Malhotra A, Zhao H, Brophy M, Shi Y, O’Leary T, Gleason T, Przygodzki R, Pyarajan S, Muralidhar S, Gaziano J, Huang G, Concato J, Siever L, DeLisi L, Kimbrel N, Beckham J, Swann A, Kosten T, Fanous A, Aslan M, Harvey P. Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. Molecular Psychiatry 2024, 29: 2399-2407. PMID: 38491344, DOI: 10.1038/s41380-024-02472-1.Peer-Reviewed Original ResearchBipolar I disorderSuicidal behaviorElectronic health recordsPolygenic scoresVeterans Health AdministrationSelf-reported SBColumbia-Suicide Severity Rating ScaleBipolar I disorder patientsCorrelates of suicidal behaviorClasses of psychotropic medicationsSelf-injurious behaviorHealth recordsSeverity Rating ScaleDiagnosed mental illnessAssociated with clinical variablesElectronic health record codesEHR domainDepressive disorderC-SSRSLifetime diagnosisSubstance-relatedPsychotropic medicationsSuicidal ideationExternalizing behaviorsSuicide attemptsVal/Met BDNF as a genetic risk for a false sense of security in post-discharge suicide risk
Rufino K, Goli P, Patriquin M, Kosten T, Nielsen D, Salas R. Val/Met BDNF as a genetic risk for a false sense of security in post-discharge suicide risk. Journal Of Affective Disorders 2024, 354: 98-103. PMID: 38447916, DOI: 10.1016/j.jad.2024.03.001.Peer-Reviewed Original ResearchSuicide riskAssociated with suicide riskHigher risk of suicide attemptRisk of suicide attemptSuicidal ideation levelsMet variantSuicidal ideation scoresHigh riskPost-discharge suicidesPsychiatric inpatient carePost-discharge periodPsychiatric inpatientsIdeation scoresSuicidal ideationSuicide attemptsInpatient treatmentNo significant associationAssociated with such riskInpatient careDiverse sampleSuicideBDNFIdeational levelGenetic riskInpatients