2020
A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesIntervention groupControl groupUsual careMultifactorial interventionRate of hospitalizationPrimary care practicesCluster-randomized trialCommunity-dwelling adultsFirst-event analysisYears of ageHealth care systemRate of fallElectronic health recordsBaseline characteristicsPrimary outcomeRandomized trialsMean ageEfficacy trialsIndividualized planCare practicesInjuryMultifactorial strategyEvent rates
2018
Effect of testosterone replacement on measures of mobility in older men with mobility limitation and low testosterone concentrations: secondary analyses of the Testosterone Trials
Bhasin S, Ellenberg SS, Storer TW, Basaria S, Pahor M, Stephens-Shields AJ, Cauley JA, Ensrud KE, Farrar JT, Cella D, Matsumoto AM, Cunningham GR, Swerdloff RS, Wang C, Lewis CE, Molitch ME, Barrett-Connor E, Crandall JP, Hou X, Preston P, Cifelli D, Snyder PJ, Gill TM. Effect of testosterone replacement on measures of mobility in older men with mobility limitation and low testosterone concentrations: secondary analyses of the Testosterone Trials. The Lancet Diabetes & Endocrinology 2018, 6: 879-890. PMID: 30366567, PMCID: PMC6816466, DOI: 10.1016/s2213-8587(18)30171-2.Peer-Reviewed Original ResearchConceptsEffects of testosteroneSelf-reported mobility limitationsPlacebo-treated menTestosterone-treated menLow testosterone concentrationsPlacebo groupMobility limitationsTestosterone concentrationsTestosterone groupTestosterone TrialsOlder menHemoglobin concentrationMin walk test distanceSelf-reported physical functionPlacebo gel dailyPatient Global ImpressionBaseline gait speedShort Form-36Total testosterone concentrationsPost-intervention assessmentModified intentionTreat populationTestosterone therapyTestosterone gelForm-36
2016
Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study)
Gill TM, Pahor M, Guralnik JM, McDermott MM, King AC, Buford TW, Strotmeyer ES, Nelson ME, Sink KM, Demons JL, Kashaf SS, Walkup MP, Miller ME. Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). The BMJ 2016, 352: i245. PMID: 26842425, PMCID: PMC4772786, DOI: 10.1136/bmj.i245.Peer-Reviewed Original ResearchConceptsSerious fall injuriesPhysical activity programHealth education programsStructured physical activity programSedentary older peopleFall injuriesHospital admissionFunctional limitationsActivity programOlder peopleModerate-intensity physical activity programShort Physical Performance Battery scorePhysical Performance Battery scoreNon-vertebral fracturesPrespecified secondary outcomesPhysical activity groupRelated hospital admissionsHealth education groupStructured physical activityBalance training activitiesRate of fallSecondary outcomesStretching exercisesIntervention assignmentClinical trials
2002
A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home
Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Byers A. A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home. New England Journal Of Medicine 2002, 347: 1068-1074. PMID: 12362007, DOI: 10.1056/nejmoa020423.Peer-Reviewed Original ResearchConceptsFunctional declineControl groupElderly personsDisability scoresIntervention groupLower-body dressingMore severe disabilityPrevent Functional DeclineHome-based intervention programFrequency of admissionHome-based programSuch functional declinePersons 75 yearsBase lineSevere frailtyPrimary outcomeSubstantial morbidityModerate frailtyMuscle strengthDisability ScalePhysical abilityPhysical therapyDaily livingNursing homesSix months
2000
Environmental Hazards and the Risk of Nonsyncopal Falls in the Homes of Community-Living Older Persons
Gill T, Williams C, Tinetti M. Environmental Hazards and the Risk of Nonsyncopal Falls in the Homes of Community-Living Older Persons. Medical Care 2000, 38: 1174-1183. PMID: 11186296, DOI: 10.1097/00005650-200012000-00004.Peer-Reviewed Original ResearchConceptsNonsyncopal fallsOlder personsCommunity-living older personsProspective cohort studyBalance/gaitYears of ageFall calendarsCohort studyResearch nursesRoom assessmentFall preventionRelative riskSlip hazardsConsistent associationNumber of participantsRiskFace validityPhone callsHigh face validityProbability sampleAgeAssociationFallYearsStandard instrumentsHealth, Functional, and Psychological Outcomes Among Older Persons with Chronic Dizziness
Tinetti M, Williams C, Gill T. Health, Functional, and Psychological Outcomes Among Older Persons with Chronic Dizziness. Journal Of The American Geriatrics Society 2000, 48: 417-421. PMID: 10798469, DOI: 10.1111/j.1532-5415.2000.tb04700.x.Peer-Reviewed Original ResearchConceptsSelf-rated healthChronic dizzinessDepressive symptomsInstrumental activitiesDaily livingOlder personsProspective cohort studyGoals of carePotential confounding factorsCohort studyAdverse outcomesDizzinessAge 72Clinical strategiesBaseline levelsConfounding factorsSocial disabilityDiscrete diseaseSymptomsHealth conditionsMarginal significanceHospitalizationSyncopeOutcomesPsychological outcomes
1999
Preventing Falls: To Modify the Environment or the Individual?
Gill T. Preventing Falls: To Modify the Environment or the Individual? Journal Of The American Geriatrics Society 1999, 47: 1471-1472. PMID: 10591245, DOI: 10.1111/j.1532-5415.1999.tb01570.x.Commentaries, Editorials and LettersMismatches Between the Home Environment and Physical Capabilities Among Community‐Living Older Persons
Gill T, Robison J, Williams C, Tinetti M. Mismatches Between the Home Environment and Physical Capabilities Among Community‐Living Older Persons. Journal Of The American Geriatrics Society 1999, 47: 88-92. PMID: 9920235, DOI: 10.1111/j.1532-5415.1999.tb01906.x.Peer-Reviewed Original ResearchConceptsOlder personsHomes of participantsCommunity-living older personsTub/showerAdverse functional outcomesPopulation-based cohortCross-sectional studySame deficitSpecific deficitsPhysical performance assessmentPhysical capabilitiesFunctional outcomeEpidemiologic linkGeneral communityPrevalenceComprehensive interviewObstructed pathwaysDeficitsEveryday functionGrab barsObserved deficitsParticipantsGaitPersonsNew Haven