2023
Relationship Between Distressing Symptoms and Changes in Disability After Major Surgery Among Community-living Older Persons
Gill T, Han L, Feder S, Gahbauer E, Leo-Summers L, Becher R. Relationship Between Distressing Symptoms and Changes in Disability After Major Surgery Among Community-living Older Persons. Annals Of Surgery 2023, 279: 65-70. PMID: 37389893, PMCID: PMC10761592, DOI: 10.1097/sla.0000000000005984.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overDisabled PersonsElective Surgical ProceduresHospitalizationHumansPatient DischargeProspective StudiesConceptsMajor surgeryDistressing symptomsElective surgeryFunctional outcomeOlder personsCommunity-living older personsMultiple distressing symptomsSocioeconomic disadvantageCommunity-living personsTiming of surgerySerious health eventsNumber of disabilitiesSurgerySignificant associationSymptomsHealth eventsRate ratioPotential targetDisabilityUnit increaseDeleterious effectsOutcomesPersonsMultimorbidityAdmissionComparisons Between GPS-based and Self-reported Life-space Mobility in Older Adults.
Bai C, Zapata R, Karnati Y, Smail E, Hajduk A, Gill T, Ranka S, Manini T, Mardini M. Comparisons Between GPS-based and Self-reported Life-space Mobility in Older Adults. AMIA Annual Symposium Proceedings 2023, 2022: 212-220. PMID: 37128363.Peer-Reviewed Original Research
2021
Association Between Neighborhood Disadvantage and Functional Well-being in Community-Living Older Persons
Gill TM, Zang EX, Murphy TE, Leo-Summers L, Gahbauer EA, Festa N, Falvey JR, Han L. Association Between Neighborhood Disadvantage and Functional Well-being in Community-Living Older Persons. JAMA Internal Medicine 2021, 181: 1297-1304. PMID: 34424276, PMCID: PMC8383163, DOI: 10.1001/jamainternmed.2021.4260.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedFemaleFunctional StatusHealthy Life ExpectancyHousing QualityHumansIndependent LivingLongitudinal StudiesMaleMental HealthNeighborhood CharacteristicsPrognosisPsychosocial FunctioningQuality of LifeSocial Determinants of HealthSocioeconomic FactorsUnited StatesConceptsProspective longitudinal cohort studyCommunity-living older personsAge 70 yearsActive life expectancyLongitudinal cohort studyOlder personsCohort studyPrognostic factorsLife expectancyArea deprivation index scoreCommunity-living personsPrecipitating Events ProjectDeprivation index scoreDisabled life expectancyAge 90 yearsArea Deprivation IndexPublic health initiativesPublic health interventionsNeighborhood disadvantageGreater percentageResource-poor environmentsIndividual-level socioeconomic characteristicsMean ageMAIN OUTCOMEDaily living
2020
Functional Effects of Intervening Illnesses and Injuries After Hospitalization for Major Surgery in Community-living Older Persons
Gill TM, Han L, Gahbauer EA, Leo-Summers L, Murphy TE, Becher RD. Functional Effects of Intervening Illnesses and Injuries After Hospitalization for Major Surgery in Community-living Older Persons. Annals Of Surgery 2020, 273: 834-841. PMID: 33074902, PMCID: PMC8370041, DOI: 10.1097/sla.0000000000004438.Peer-Reviewed Original ResearchConceptsMajor surgeryED visitsRestricted activityFunctional statusFunctional declineOlder personsCommunity-living older personsAdjusted hazard ratioAdverse functional outcomesCommunity-living personsEmergency department visitsTraditional risk factorsCorresponding odds ratiosFunctional effectsIllness/injuryHazard ratioDepartment visitsFunctional recoveryFunctional outcomeRisk factorsOdds ratioHospitalizationSurgeryInjuryVisitsCohort Profile: The Precipitating Events Project (PEP Study)
Gill T, Han L, Gahbauer EA, Leo-Summers L, Murphy TE. Cohort Profile: The Precipitating Events Project (PEP Study). The Journal Of Nutrition, Health & Aging 2020, 24: 438-444. PMID: 32242212, PMCID: PMC7322244, DOI: 10.1007/s12603-020-1341-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleProspective StudiesConceptsPrecipitating Events ProjectPEP studyComprehensive home-based assessmentsEpidemiology of disabilityAge 70 yearsHealth care utilizationGreater New HavenLarge health planParticipant-level dataHome-based assessmentEnd of lifeCare utilizationDeath certificatesMedicare claimsDepressive symptomsOngoing longitudinal studyDisabling processEligible membersOlder personsHealth plansLongitudinal studyMethodologic researchCompletion ratesOriginal reportQualified investigators
2019
Short-Term Disability Fluctuations in Late Life
Stolz E, Gill T, Mayerl H, Freidl W. Short-Term Disability Fluctuations in Late Life. The Journals Of Gerontology Series B 2019, 74: e135-e140. PMID: 31298701, PMCID: PMC6777769, DOI: 10.1093/geronb/gbz089.Peer-Reviewed Original Research
2018
Functional Trajectories Before and After Major Surgery in Older Adults
Stabenau HF, Becher RD, Gahbauer EA, Leo-Summers L, Allore HG, Gill TM. Functional Trajectories Before and After Major Surgery in Older Adults. Annals Of Surgery 2018, 268: 911-917. PMID: 29356710, PMCID: PMC6521949, DOI: 10.1097/sla.0000000000002659.Peer-Reviewed Original ResearchConceptsMajor surgeryNonelective surgeryFunctional trajectoriesSevere disabilityOlder adultsCourse of disabilityFirst major surgeryPersons 70 yearsProspective cohort studyCohort studyFunctional prognosisModerate disabilityPartial improvementSurgeryPremorbid functionOlder personsStudy periodAnalytic sampleLittle improvementRapid improvementTrajectory groupsMild disabilityMost participantsDisabilityGradual improvement
2016
Sex Differences in Concomitant Trajectories of Self-Reported Disability and Measured Physical Capacity in Older Adults
Botoseneanu A, Allore HG, de Leon C, Gahbauer EA, Gill TM. Sex Differences in Concomitant Trajectories of Self-Reported Disability and Measured Physical Capacity in Older Adults. The Journals Of Gerontology Series A 2016, 71: 1056-1062. PMID: 27071781, PMCID: PMC4945890, DOI: 10.1093/gerona/glw038.Peer-Reviewed Original ResearchConceptsSelf-reported disabilityShort Physical Performance Battery scorePhysical Performance Battery scoreGrip strengthPhysical capacityFunctional statusBattery scoreShort Physical Performance BatterySelf-reported functional statusChronic disease statusPhysical Performance BatteryWeak grip strengthPrecipitating Events ProjectHealth risk factorsSex-specific comparisonsAge-related declineFunctional indicatorsDisability ScaleRisk factorsOlder womenPerformance BatterySociodemographic characteristicsOlder adultsDisabilityWomenRestricting Symptoms Before and After Admission to Hospice
Cheraghlou S, Gahbauer EA, Leo-Summers L, Stabenau HF, Chaudhry SI, Gill TM. Restricting Symptoms Before and After Admission to Hospice. The American Journal Of Medicine 2016, 129: 754.e7-754.e15. PMID: 26968471, PMCID: PMC4914433, DOI: 10.1016/j.amjmed.2016.02.017.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overChest PainCognitive DysfunctionCohort StudiesDepressionDiarrheaDizzinessDyspneaEdemaFatigueFemaleHospice CareHospicesHumansIndependent LivingLongitudinal StudiesMaleMemory DisordersMuscle WeaknessMusculoskeletal PainNauseaPatient AdmissionPrevalenceProspective StudiesSleep Wake DisordersUnited StatesUrologic DiseasesVision DisordersVomitingConceptsHospice admissionEnd of lifeDistressing symptomsMean numberCommunity-dwelling older personsMonthly telephone interviewsOngoing cohort studyMonths of lifeEffect of hospiceHospice treatmentAdmission diagnosisEarly referralMedian durationCohort studySymptom prevalenceSuch symptomsSymptom increasesAdmissionPsychological symptomsSymptomsOlder personsRestricted activityHospiceTelephone interviewsPrevalence
2015
The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people
Gill TM, Gahbauer EA, Han L, Allore HG. The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people. The BMJ 2015, 350: h2361. PMID: 25995357, PMCID: PMC4443433, DOI: 10.1136/bmj.h2361.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCohort StudiesConnecticutDementiaDisability EvaluationDisabled PersonsDisease ProgressionFemaleFrail ElderlyGeriatric AssessmentHospitalizationHumansMaleMultiple Organ FailureNeoplasmsPrognosisProspective StudiesSeverity of Illness IndexTerminal CareUnited StatesConceptsCourse of disabilityProspective cohort studyHospital admissionTrajectories of disabilitySeverity of disabilityCatastrophic disabilitySevere disabilityCohort studyAcute hospital admissionPalliative care approachMultiple hospital admissionsAdvance care planningPersonal care needsEnd of lifeDisability scoresOlder patientsPotential confoundersOccurrence of admissionMultivariable modelCare planningMAIN OUTCOMECare approachDaily livingCare needsAdmissionFunctional Trajectories Among Older Persons Before and After Critical Illness
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.Peer-Reviewed Original ResearchConceptsIntensive care unitLong-term mortalityCritical illnessICU admissionModerate disabilityOlder personsMinimal disabilitySevere disabilityFunctional trajectoriesFunctional declineEarly deathProspective cohort studyDay of admissionPersons 70 yearsGoals of careRisk of deathShort-term mortalityGreater New HavenSignificant functional declineICU lengthCohort studyHospital dischargePremorbid disabilityCare unitMechanical ventilation
2014
Disentangling the Disabling Process: Insights From the Precipitating Events Project
Gill TM. Disentangling the Disabling Process: Insights From the Precipitating Events Project. The Gerontologist 2014, 54: 533-549. PMID: 25035454, PMCID: PMC4155452, DOI: 10.1093/geront/gnu067.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsActivities of Daily LivingAgedDisability EvaluationDisabled PersonsFrail ElderlyHumansProblem SolvingConceptsHealth care utilizationPrecipitating Events ProjectPEP studyOlder personsCare utilizationEpidemiology of disabilityCommunity-living personsHome-based assessmentFrequency of assessmentDisability episodeEnd of lifeFunctional statusDaily livingOngoing longitudinal studyMedicare dataDisabling processEffective interventionsLonger durationLongitudinal studyDisabilityRecent linkageEvents ProjectPersonsSymptomsMorbid
2012
Risk factors and precipitants of long-term disability in community mobility: a cohort study of older persons.
Gill TM, Gahbauer EA, Murphy TE, Han L, Allore HG. Risk factors and precipitants of long-term disability in community mobility: a cohort study of older persons. Annals Of Internal Medicine 2012, 156: 131-40. PMID: 22250144, PMCID: PMC3278794, DOI: 10.7326/0003-4819-156-2-201201170-00009.Peer-Reviewed Original ResearchConceptsLong-term disabilityRisk factorsOlder personsCohort studyCommunity mobilityShort Physical Performance BatteryMultivariate hazard ratiosProspective cohort studyPhysical Performance BatteryMultiple risk factorsCandidate risk factorsSpecific risk factorsNational InstituteLong-term mobility disabilityHazard ratioAbsolute riskPerformance BatteryPotential precipitantsMobility disabilityRestricted activityOlder ageObserved associationsInitial onsetStrong associationQuarter mile
2010
Change in Disability After Hospitalization or Restricted Activity in Older Persons
Gill TM, Allore HG, Gahbauer EA, Murphy TE. Change in Disability After Hospitalization or Restricted Activity in Older Persons. JAMA 2010, 304: 1919-1928. PMID: 21045098, PMCID: PMC3124926, DOI: 10.1001/jama.2010.1568.Peer-Reviewed Original ResearchConceptsHazard ratioPhysical frailtySevere disabilityOlder personsMild disabilityMultivariable hazard ratiosProspective cohort studyCommunity-living personsFall-related injuriesGreater New HavenState of disabilityLikelihood of recoveryCohort studyAbsolute riskFrail individualsHospitalizationDaily livingNonfrail individualsRestricted activityInjuryTelephone interviewsFrailtyIllnessMonthsDisabilityTrajectories of Disability in the Last Year of Life
Gill TM, Gahbauer EA, Han L, Allore HG. Trajectories of Disability in the Last Year of Life. New England Journal Of Medicine 2010, 362: 1173-1180. PMID: 20357280, PMCID: PMC2877372, DOI: 10.1056/nejmoa0909087.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAged, 80 and overBayes TheoremCause of DeathDisability EvaluationDisabled PersonsDisease ProgressionHumansLongitudinal StudiesConceptsCourse of disabilityDisability trajectoriesOrgan failureAdvanced dementiaSudden deathOlder personsSevere disabilityCommunity-dwelling older personsTrajectories of disabilityLevel of disabilityCatastrophic disabilityEnd of lifeProgressive disabilityFunctional statusDeath certificatesCommon conditionBaseline assessmentPredominant trajectoriesMonthly interviewsDeathDisabilityLongitudinal studyDementiaFrailtyDecedents
2009
Indications, Labeling, and Outcomes Assessment for Drugs Aimed at Improving Functional Status in Older Persons: A Conversation Between Aging Researchers and FDA Regulators
Bhasin S, Espeland M, Evans W, Ferrucci L, Fried L, Gill T, Pahor M, Studenski S, Guralnik J, Nayfield S, Romashkin S, Perlstein R, Burke L, Parks M. Indications, Labeling, and Outcomes Assessment for Drugs Aimed at Improving Functional Status in Older Persons: A Conversation Between Aging Researchers and FDA Regulators. The Journals Of Gerontology Series A 2009, 64A: 487-491. PMID: 19270182, PMCID: PMC2657175, DOI: 10.1093/gerona/gln042.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAgingCognition DisordersDose-Response Relationship, DrugFemaleFrail ElderlyGeriatric AssessmentHumansInterdisciplinary CommunicationMaleOutcome Assessment, Health CarePharmaceutical PreparationsPhysical FitnessPractice Guidelines as TopicResearchRisk AssessmentSensitivity and SpecificityUnited StatesUnited States Food and Drug Administration
2008
Serum Micronutrient Concentrations and Decline in Physical Function Among Older Persons
Bartali B, Frongillo EA, Guralnik JM, Stipanuk MH, Allore HG, Cherubini A, Bandinelli S, Ferrucci L, Gill TM. Serum Micronutrient Concentrations and Decline in Physical Function Among Older Persons. JAMA 2008, 299: 308-315. PMID: 18212315, PMCID: PMC2645790, DOI: 10.1001/jama.299.3.308.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAgingFemaleHumansLogistic ModelsLongitudinal StudiesMaleMicronutrientsMotor SkillsNutritional StatusVitamin EConceptsShort Physical Performance Battery scorePhysical Performance Battery scorePhysical functionLow serum concentrationsVitamin EOlder personsBattery scorePotential confoundersSerum concentrationsOdds ratioShort Physical Performance BatteryCommunity-living older adultsPhysical Performance BatteryPublic health priorityPersons 65 yearsSerum micronutrient concentrationsLogistic regression analysisOnset of disabilityBaseline examinationPotential deleterious effectsSubsequent declineClinical trialsLowest quartilePopulation registryFunctional decline
2006
Effects of a Physical Activity Intervention on Measures of Physical Performance: Results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study
Pahor M, Blair S, Espeland M, Fielding R, Gill T, Guralnik J, Hadley E, King A, Kritchevsky S, Maraldi C, Miller M, Newman A, Rejeski W, Romashkan S, Studenski S. Effects of a Physical Activity Intervention on Measures of Physical Performance: Results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study. The Journals Of Gerontology Series A 2006, 61: 1157-1165. PMID: 17167156, DOI: 10.1093/gerona/61.11.1157.Peer-Reviewed Original ResearchConceptsShort Physical Performance BatteryPhysical activity interventionsSPPB scoreMobility disabilityActivity interventionsPA interventionsPA groupBaseline short physical performance batteryComprehensive physical activity interventionModerate-intensity PA interventionElders Pilot StudyStructured PA interventionPhysical performanceDaily living (ADL) disabilityMajor mobility disabilityPhysical Performance BatteryHealth education interventionPhysical performance measuresDistal health outcomesLifestyle interventionSPPB performanceMore distal health outcomesLower incidenceSedentary personsPerformance Battery
2004
Hospitalization, Restricted Activity, and the Development of Disability Among Older Persons
Gill TM, Allore HG, Holford TR, Guo Z. Hospitalization, Restricted Activity, and the Development of Disability Among Older Persons. JAMA 2004, 292: 2115-2124. PMID: 15523072, DOI: 10.1001/jama.292.17.2115.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCohort StudiesDisabled PersonsFemaleFrail ElderlyHospitalizationHumansMaleProportional Hazards ModelsProspective StudiesConceptsDevelopment of disabilityPhysical frailtyRestricted activityDaily livingOlder personsProspective cohort studyMonthly telephone interviewsMonths of hospitalizationPopulation attributable fractionGreater New HavenPrevention of disabilityOccurrence of disabilityCohort studyFrail participantsHospital admissionNonfrail participantsMultivariable hazardMAIN OUTCOMEDisabling processHospitalizationTelephone interviewsDisability onsetGeneral communityOlder adultsFrailtyRecovery From Disability Among Community-Dwelling Older Persons
Hardy SE, Gill TM. Recovery From Disability Among Community-Dwelling Older Persons. JAMA 2004, 291: 1596-1602. PMID: 15069047, DOI: 10.1001/jama.291.13.1596.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overDisability EvaluationDisabled PersonsFemaleHumansMaleProspective StudiesRecovery of FunctionTime FactorsConceptsOlder personsADL functionCommunity-dwelling older personsProspective cohort studyMonthly telephone interviewsCommunity-dwelling personsHigh-risk groupDuration of disabilityDuration of recoveryCourse of recoveryLikelihood of recoveryDisability episodeCohort studyMajority of participantsTrue incidenceChronic conditionsPhysical frailtyDaily livingDemographic featuresCognitive functionTelephone interviewsMonthsMonthly assessmentsPertinent subgroupsDisability