1999
Childhood-onset schizophrenia: progressive brain changes during adolescence
Giedd J, Jeffries N, Blumenthal J, Castellanos FX, Vaituzis A, Fernandez T, Hamburger S, Liu H, Nelson J, Bedwell J, Tran L, Lenane M, Nicolson R, Rapoport J. Childhood-onset schizophrenia: progressive brain changes during adolescence. Biological Psychiatry 1999, 46: 892-898. PMID: 10509172, DOI: 10.1016/s0006-3223(99)00072-4.Peer-Reviewed Original ResearchConceptsBrain anomaliesVentricular volumeTotal cerebrumLateral ventricleCOS groupDuration of illnessProgressive brain changesBrain magnetic resonanceStructural brain anomaliesBrain MRI studiesGender-matched controlsMean age 14Age-related changesAdult patientsAdult schizophreniaBrain changesMRI studiesControl groupLarger sample sizeBrain tissueBrain developmentHippocampusProgressionDiagnostic group differencesEarly adulthoodProgressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study
Rapoport JL, Giedd JN, Blumenthal J, Hamburger S, Jeffries N, Fernandez T, Nicolson R, Bedwell J, Lenane M, Zijdenbos A, Paus T, Evans A. Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study. JAMA Psychiatry 1999, 56: 649-654. PMID: 10401513, DOI: 10.1001/archpsyc.56.7.649.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetCerebral CortexCerebral VentriclesChildFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleSchizophrenia, ChildhoodConceptsChildhood-onset schizophreniaCortical gray matter volumeWhite matter volumeDisease-specific patternsGray matter volumeMatter volumeHealthy controlsCortical changesBrain tissueGray matterSchizophrenia groupLongitudinal magnetic resonance imaging studyBrain developmentBrain ventricular enlargementProgressive cortical changesMagnetic resonance imaging studyBrain magnetic resonanceEarly-onset schizophreniaTemporal gray matterAbnormal brain developmentResonance imaging studyVentricular enlargementMean ageOnset schizophreniaPatient's illnessApolipoprotein E alleles in childhood‐onset schizophrenia
Fernandez T, Yan W, Hamburger S, Rapoport J, Saunders A, Schapiro M, Ginns E, Sidransky E. Apolipoprotein E alleles in childhood‐onset schizophrenia. American Journal Of Medical Genetics 1999, 88: 211-213. PMID: 10206244, DOI: 10.1002/(sici)1096-8628(19990416)88:2<211::aid-ajmg20>3.0.co;2-m.Peer-Reviewed Original Research
1998
Brief Report: Association of Sex Chromosome Anomalies With Childhood-Onset Psychotic Disorders
KUMRA S, WIGGS E, KRASNEWICH D, MECK J, SMITH A, BEDWELL J, FERNANDEZ T, JACOBSEN L, LENANE M, RAPOPORT J. Brief Report: Association of Sex Chromosome Anomalies With Childhood-Onset Psychotic Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 292-296. PMID: 9519634, DOI: 10.1097/00004583-199803000-00014.Peer-Reviewed Original ResearchConceptsChildhood-onset schizophreniaPsychotic disordersPediatric patientsSex chromosome anomaliesSubgroup of patientsAdult-onset schizophreniaChromosome anomaliesLoss of balanceUnspecified psychosisTreatment trialsGeneral populationPatientsSex chromosome aneuploidyMental healthDisordersNational InstituteAffected individualsEnvironmental insultsCytogenetic screeningSchizophreniaChromosome aneuploidyChildrenClozapinePsychosisInsult