2005
Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes
Sabbagh Y, Carpenter TO, Demay MB. Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 9637-9642. PMID: 15976027, PMCID: PMC1172249, DOI: 10.1073/pnas.0502249102.Peer-Reviewed Original ResearchConceptsParathyroid hormone levelsMineral ion homeostasisRachitic changesHormone levelsAbnormal mineral ion homeostasisDihydroxyvitamin D levelsVitamin D deficiencyDegree of hypophosphatemiaHypertrophic chondrocyte layerVitamin D receptorHypertrophic chondrocytesNormal phosphorus levelsGrowth plate maturationD deficiencyD levelsNormal calciumD receptorChondrocyte layerHypophosphatemiaVDR actionChondrocyte apoptosisNull miceRicketsCaspase-mediated apoptosisHypercalcemia
1995
Media Calcium Attenuates Mitochondrial 1,25(OH)2D Production in Phosphorus or Vitamin D-Deprived Rats
Carpenter T, Ellis B. Media Calcium Attenuates Mitochondrial 1,25(OH)2D Production in Phosphorus or Vitamin D-Deprived Rats. Pediatric Research 1995, 37: 726-730. PMID: 7544454, DOI: 10.1203/00006450-199506000-00009.Peer-Reviewed Original ResearchConceptsVitamin D deprivationLow phosphorus dietVitamin DPhosphorus dietPrimary physiologic regulatorCalcium effectDeficient dietLong-term exposureCalcium modulatesMedium calciumPhysiologic regulatorRatsControl dietMarked inhibitionEffect of calciumStimulatory responseRenal mitochondriaExtramitochondrial calciumDietWkBasal activityPTHTerm exposureCalciumDeprivation