2024
Impact of burosumab on lower limb alignment in children with X-linked hypophosphatemia
Frumberg D, Merritt J, Chen A, Carpenter T. Impact of burosumab on lower limb alignment in children with X-linked hypophosphatemia. Journal Of The Pediatric Orthopaedic Society Of North America 2024, 6: 100012. DOI: 10.1016/j.jposna.2024.100012.Peer-Reviewed Original ResearchMechanical femoral-tibial angleLower limbsNeutral alignmentLower limb malalignmentLower limb alignmentLevel of Evidence IIIX-linked hypophosphatemiaLower limb deformitiesFemoral-tibial angleLower limb radiographsValgus limbsLimb malalignmentImpact of burosumabLimb alignmentLimb radiographsCrossover armAngular deformityNormal limbsLimb deformitiesLimbVarusMalalignmentClinically normal limbsHemiepiphysiodesisBaseline
1998
Osteocalcin Production in Primary Osteoblast Cultures Derived from Normal and Hyp Mice
Carpenter T, Moltz K, Ellis B, Andreoli M, McCarthy T, Centrella M, Bryan D, Gundberg C. Osteocalcin Production in Primary Osteoblast Cultures Derived from Normal and Hyp Mice. Endocrinology 1998, 139: 35-43. DOI: 10.1210/en.139.1.35.Peer-Reviewed Original ResearchExposure to 1,25(OH)2D3Hyp micePrimary osteoblast culturesOsteoblast culturesOsteocalcin productionHuman X-linked hypophosphatemiaMurine osteoblastsMaturation-dependent fashionOsteocalcin messenger RNAHyp mouse modelEffects of 1,25(OH)2D3Response to 1,25(OH)2D3X-linked hypophosphatemiaMessenger RNASpecies-specific effectsInhibit osteoblast differentiationRegulation of osteocalcinMurine culturesIn vivo milieuMutant strainPrimary culturesStimulate osteocalcinDay 9MiceOsteocalcin