1998
Osteocalcin Production in Primary Osteoblast Cultures Derived from Normal and Hyp Mice
Carpenter T, Moltz K, Ellis B, Andreoli M, McCarthy T, Centrella M, Bryan D, Gundberg C. Osteocalcin Production in Primary Osteoblast Cultures Derived from Normal and Hyp Mice. Endocrinology 1998, 139: 35-43. DOI: 10.1210/en.139.1.35.Peer-Reviewed Original ResearchExposure to 1,25(OH)2D3Hyp micePrimary osteoblast culturesOsteoblast culturesOsteocalcin productionHuman X-linked hypophosphatemiaMurine osteoblastsMaturation-dependent fashionOsteocalcin messenger RNAHyp mouse modelEffects of 1,25(OH)2D3Response to 1,25(OH)2D3X-linked hypophosphatemiaMessenger RNASpecies-specific effectsInhibit osteoblast differentiationRegulation of osteocalcinMurine culturesIn vivo milieuMutant strainPrimary culturesStimulate osteocalcinDay 9MiceOsteocalcin
1996
Osteocalcin abnormalities in Hyp mice reflect altered genetic expression and are not due to altered clearance, affinity for mineral, or ambient phosphorus levels
Carpenter T, Gundberg C. Osteocalcin abnormalities in Hyp mice reflect altered genetic expression and are not due to altered clearance, affinity for mineral, or ambient phosphorus levels. Endocrinology 1996, 137: 5213-5219. DOI: 10.1210/en.137.12.5213.Peer-Reviewed Original ResearchDoses of 1,25-(OH)2D3Hyp miceCirculating osteocalcinNormal animalsIncreased serum osteocalcin levelsOsteocalcin mRNAResponse to 1,25-dihydroxyvitamin D3Response to 1,25-(OH)2D3Serum osteocalcin levelsC57 BL/6 miceDietary phosphorus deprivationRenal wastingOsteocalcin levelsDaily doseSingle doseBL/6 miceCirculating levelsParadoxical decreaseAffinity of osteocalcinU-calciumBone osteocalcinMiceOsteocalcinOsteocalcin productionClearance