Characterization of FN1–FGFR1 and novel FN1–FGF1 fusion genes in a large series of phosphaturic mesenchymal tumors
Lee JC, Su SY, Changou CA, Yang RS, Tsai KS, Collins MT, Orwoll ES, Lin CY, Chen SH, Shih SR, Lee CH, Oda Y, Billings SD, Li CF, Nielsen GP, Konishi E, Petersson F, Carpenter TO, Sittampalam K, Huang HY, Folpe AL. Characterization of FN1–FGFR1 and novel FN1–FGF1 fusion genes in a large series of phosphaturic mesenchymal tumors. Modern Pathology 2016, 29: 1335-1346. PMID: 27443518, DOI: 10.1038/modpathol.2016.137.Peer-Reviewed Original ResearchConceptsPhosphaturic mesenchymal tumorFN1-FGFR1 fusionMesenchymal tumorsGiant cell tumorFusion geneSolitary fibrous tumorPotential morphologic mimicsFN1-FGFR1Cell tumorsOverall prevalenceFGF23 secretionFibrous tumorFusion statusMorphologic mimicsLarge seriesAutocrine loopAdditional casesTumorsWestern blotPrior studiesFurther studiesSitu hybridization analysisDirect sequencingFusion typeImmunohistochemistry