2024
Effect of endoscopic ultrasound guided celiac plexus block on the palliation of pain in chronic pancreatitis (EPOCH Trial): study protocol for a randomized multicenter sham-controlled trial {1}
Wilcox C, Bang J, Buxbaum J, Gardner T, Hawes R, Kedia P, Mardini S, Muniraj T, Navaneethan U, Oza V, Tarnasky P, Thakkar S, Waxman I, Varadarajulu S. Effect of endoscopic ultrasound guided celiac plexus block on the palliation of pain in chronic pancreatitis (EPOCH Trial): study protocol for a randomized multicenter sham-controlled trial {1}. Trials 2024, 25: 676. PMID: 39396987, PMCID: PMC11472533, DOI: 10.1186/s13063-024-08478-y.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAutonomic Nerve BlockCeliac PlexusEndosonographyHumansMulticenter Studies as TopicNerve BlockPain MeasurementPalliative CarePancreatitis, ChronicProspective StudiesRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesConceptsCeliac plexus blockAbdominal painChronic pancreatitisVisual analog scalePlexus blockSham-controlled trialRandomized sham-controlled trialEndoscopic ultrasound-guided celiac plexus blockEffectiveness of endoscopic ultrasoundBrief Pain Inventory Short FormDocumented chronic pancreatitisPainful chronic pancreatitisPalliation of painTime of EUSTreatment of abdominal painPain scoresBPI-SFSteroid combinationsAnalog scaleEndoscopic ultrasoundProspective studyCeliac plexusRandomized trialsShort formPancreatitis
2023
Clinical predictive value of renalase in post-ERCP pancreatitis
Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Clinical predictive value of renalase in post-ERCP pancreatitis. Gastrointestinal Endoscopy 2023, 99: 822-825.e1. PMID: 38103747, DOI: 10.1016/j.gie.2023.12.020.Peer-Reviewed Original ResearchPost-ERCP pancreatitisRenalase levelsPlasma renalase levelsProspective cohort studyPotential clinical roleAcute experimental pancreatitisLongitudinal regression modelsPEP patientsPlasma renalaseCohort studyTertiary hospitalClinical roleExperimental pancreatitisRenalaseAbstractTextERCPPancreatitisFurther studiesAIMSRegression modelsS11 Cholecystectomy Reduces the Odds of Inpatient Mortality in Patients With Acute Biliary Pancreatitis
Restrepo D, Doshi R, Nawaz A, Chaar A, Kothari T, Laine L, Muniraj T. S11 Cholecystectomy Reduces the Odds of Inpatient Mortality in Patients With Acute Biliary Pancreatitis. The American Journal Of Gastroenterology 2023, 118: s9-s10. DOI: 10.14309/01.ajg.0000949684.33264.0a.Peer-Reviewed Original ResearchSerial serum lipase testing after the initial diagnostic workup for inpatients with acute pancreatitis: What is the evidence?
Magier S, Muniraj T, Merchant N. Serial serum lipase testing after the initial diagnostic workup for inpatients with acute pancreatitis: What is the evidence? Cleveland Clinic Journal Of Medicine 2023, 90: 341-343. PMID: 37263664, DOI: 10.3949/ccjm.90a.22060.Peer-Reviewed Original ResearchSa1420 FRAILTY IS ASSOCIATED WITH POOR OUTCOMES IN PATIENTS ADMITTED FOR ACUTE NECROTIZING PANCREATITIS
Nawaz A, Chaar A, Rizwan R, Restrepo D, Fetene J, Alchirazi K, Abdulkarim D, Khalid F, Doshi R, Mathialagan K, Hung K, Laine L, Muniraj T. Sa1420 FRAILTY IS ASSOCIATED WITH POOR OUTCOMES IN PATIENTS ADMITTED FOR ACUTE NECROTIZING PANCREATITIS. Gastroenterology 2023, 164: s-390. DOI: 10.1016/s0016-5085(23)01905-4.Peer-Reviewed Original Research
2022
Acute pancreatitis precedes chronic pancreatitis in the majority of patients: Results from the NAPS2 consortium
Singh V, Whitcomb D, Banks P, AlKaade S, Anderson M, Amann S, Brand R, Conwell D, Cote G, Gardner T, Gelrud A, Guda N, Forsmark C, Lewis M, Sherman S, Muniraj T, Romagnuolo J, Tan X, Tang G, Sandhu B, Slivka A, Wilcox C, Yadav D, Wilcox C, Guda N, Banks P, Conwell D, Lo S, Gelrud A, Gardner T, Baillie J, Forsmark C, Muniraj T, Sherman S, Singh V, Lewis M, Romagnuolo J, Hawes R, Cote G, Lawrence C, Anderson M, Amann S, Etemad B, DeMeo M, Kochman M, Abberbock J, Barmada M, Bauer E, Brand R, Kennard E, LaRusch J, O'Connell M, Stello K, Slivka A, Talluri J, Tang G, Whitcomb D, Wisniewski S, Yadav D, Burton F, AlKaade S, DiSario J, Sandhu B, Money M, Steinberg W. Acute pancreatitis precedes chronic pancreatitis in the majority of patients: Results from the NAPS2 consortium. Pancreatology 2022, 22: 1091-1098. PMID: 36404201, PMCID: PMC10122210, DOI: 10.1016/j.pan.2022.10.004.Peer-Reviewed Original ResearchConceptsDiagnosis of CPAcute pancreatitisChronic pancreatitisCP diagnosisAP patientsAssociation of APNorth American Pancreatitis StudiesMajority of patientsMultivariable logistic regressionDisease-related factorsNorth American cohortClinical acute pancreatitisAP episodeAbdominal painSecondary preventionMultivariable analysisExocrine insufficiencyPancreatic atrophyMore episodesUS CentersWhite raceLower oddsPatientsAmerican cohortPancreatitis
2021
Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study
Yadav D, Whitcomb D, Tang G, Slivka A, Bellin M, Consortium N, AlKaade S, Amann S, Anderson M, Banks P, Conwell D, Brand R, Cote G, Romagnuolo J, Forsmark C, Gardner T, Gelrud A, Guda N, Lewis M, Muniraj T, Sandhu B, Sherman S, Singh V, Wilcox C. Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study. Clinical Gastroenterology And Hepatology 2021, 21: 226-228.e1. PMID: 34793964, DOI: 10.1016/j.cgh.2021.11.011.Peer-Reviewed Original ResearchConceptsChronic pancreatitisCytokine-induced beta-cell dysfunctionPancreatogenic diabetes mellitusPrimary pathophysiologic defectType 3c diabetesSubset of patientsBeta-cell dysfunctionRecurrent AcuteGlucose intoleranceDiabetes mellitusPathophysiologic defectsFibrotic changesInsulin deficiencyCell dysfunctionExocrine pancreasPilot studyPancreatitisMellitusAcuteDiabetesInflammationPatientsDysfunctionInjuryPancreasCorrection to: Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain
Dunbar EK, Greer PJ, Amann ST, Alkaade S, Banks P, Brand R, Conwell DL, Forsmark CE, Gardner TB, Guda NM, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Slivka A, Wilcox CM, Yadav D, Whitcomb DC, Consortium F. Correction to: Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain. The American Journal Of Gastroenterology 2021, 117: 359-359. PMID: 34738548, DOI: 10.14309/ajg.0000000000001549.Peer-Reviewed Original ResearchPain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain
Dunbar EK, Greer PJ, Amann ST, Alkaade S, Banks P, Brand R, Conwell DL, Forsmark CE, Gardner TB, Guda NM, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Slivka A, Wilcox CM, Yadav D, Whitcomb DC, Consortium F. Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain. The American Journal Of Gastroenterology 2021, 116: 2128-2136. PMID: 34236339, PMCID: PMC8531869, DOI: 10.14309/ajg.0000000000001366.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderChronic pancreatitisSevere painPain experienceThird of patientsPain management strategiesIdentification of patientsAbsence of painInflammatory syndromePain patternsCP patientsPain categoriesPain locusStudy cohortAcute pancreatitisAdrenal axisCP subjectsPainGenetic predispositionPatientsPsychiatric conditionsGenetic risk lociPTSD riskPancreatitisStress disorder
2020
S0066 Trends and Socioeconomic Health Outcomes of Cannabis Use Among Patients With Chronic Pancreatitis
McCarty T, Chouairi F, Sharma P, Hathorn K, Muniraj T, Thompson C. S0066 Trends and Socioeconomic Health Outcomes of Cannabis Use Among Patients With Chronic Pancreatitis. The American Journal Of Gastroenterology 2020, 115: s31-s32. DOI: 10.14309/01.ajg.0000702312.62798.a5.Peer-Reviewed Original ResearchSa1027 EVALUATION OF SOCIOECONOMIC AND HEALTHCARE DISPARITIES ON SAME-ADMISSION CHOLECYSTECTOMY AFTER ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY AMONG PATIENTS WITH ACUTE GALLSTONE PANCREATITIS
Chouairi F, McCarty T, Hathorn K, Sharma P, Aslanian H, Thompson C, Jamidar P, Muniraj T. Sa1027 EVALUATION OF SOCIOECONOMIC AND HEALTHCARE DISPARITIES ON SAME-ADMISSION CHOLECYSTECTOMY AFTER ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY AMONG PATIENTS WITH ACUTE GALLSTONE PANCREATITIS. Gastroenterology 2020, 158: s-247-s-248. DOI: 10.1016/s0016-5085(20)31302-0.Peer-Reviewed Original ResearchComparative effectiveness of pharmacologic and endoscopic interventions for prevention of post-ERCP pancreatitis: a network meta-analysis
Njei B, McCarty TR, Muniraj T, Sharma P, Jamidar PA, Aslanian HR, Varadarajulu S, Navaneethan U. Comparative effectiveness of pharmacologic and endoscopic interventions for prevention of post-ERCP pancreatitis: a network meta-analysis. Endoscopy International Open 2020, 08: e29-e40. PMID: 31921982, PMCID: PMC6949176, DOI: 10.1055/a-1005-6366.Peer-Reviewed Original ResearchRectal non-steroidal anti-inflammatory drugsNon-steroidal anti-inflammatory drugsPost-ERCP pancreatitisPancreatic stent placementHigh-risk patientsStent placementEndoscopic interventionPreventive strategiesPost-endoscopic retrograde cholangiopancreatography pancreatitisCumulative ranking (SUCRA) probabilitiesEffective preventive strategiesAnti-inflammatory drugsWeb of ScienceAggressive hydrationSUCRA probabilitiesCholangiopancreatography pancreatitisCochrane DatabaseProphylactic treatmentPancreatic stentPancreatitisComparative effectivenessSystematic reviewRanking probabilityCombination of LRPatients
2019
Su1418 – Role of Therapeutic Anticoagulation in Splanchnic Vein Thrombosis Associated with Acute Pancreatitis: A Systematic Review and Descriptive Analysis
McCarty T, Jamidar P, Aslanian H, Muniraj T. Su1418 – Role of Therapeutic Anticoagulation in Splanchnic Vein Thrombosis Associated with Acute Pancreatitis: A Systematic Review and Descriptive Analysis. Gastroenterology 2019, 156: s-540. DOI: 10.1016/s0016-5085(19)38246-0.Peer-Reviewed Original ResearchChronic Pancreatitis
Schwarzenberg SJ, Uc A, Zimmerman B, Wilschanski M, Wilcox CM, Whitcomb DC, Werlin SL, Troendle D, Tang G, Slivka A, Singh VK, Sherman S, Shah U, Sandhu BS, Romagnuolo J, Rhee S, Pohl JF, Perito ER, Ooi CY, Nathan JD, Muniraj T, Morinville VD, McFerron B, Mascarenhas M, Maqbool A, Liu Q, Lin TK, Lewis M, Husain SZ, Himes R, Heyman MB, Guda N, Gonska T, Giefer MJ, Gelrud A, Gariepy CE, Gardner TB, Freedman SD, Forsmark CE, Fishman DS, Cote GA, Conwell D, Brand RE, Bellin M, Barth B, Banks PA, Anderson MA, Amann ST, Alkaade S, Abu‐El‐Haija M, Abberbock JN, Lowe ME, Yadav D. Chronic Pancreatitis. Journal Of Pediatric Gastroenterology And Nutrition 2019, 68: 566-573. PMID: 30897605, PMCID: PMC6492264, DOI: 10.1097/mpg.0000000000002279.Peer-Reviewed Original ResearchConceptsChronic pancreatitisRisk factorsGenetic risk factorsOnly risk factorEmergency room visitsInternational Study GroupAge of onsetWork/schoolDisease durationPediatric pancreatitisRoom visitsDiabetes prevalenceRadiographic findingsAppropriate statistical testsPancreatic insufficiencyChildhood onsetStudy groupSecondary analysisCohortNatural historyPancreatitisCP treatmentAdultsChildrenLength of time
2018
Cannabis Use Is Associated With Increased Risk of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Njei B, Sharma P, McCarty TR, Singh M, Haque L, Aslanian HR, Jamidar P, Muniraj T. Cannabis Use Is Associated With Increased Risk of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis. Pancreas 2018, 47: 1142-1149. PMID: 30134357, DOI: 10.1097/mpa.0000000000001143.Peer-Reviewed Original ResearchConceptsPost-endoscopic retrograde cholangiopancreatography pancreatitisIncidence risk ratioCholangiopancreatography pancreatitisCannabis useRisk of PEPEndoscopic retrograde cholangiopancreatography pancreatitisUS Nationwide Inpatient SampleRate of PEPShorter hospital stayNationwide Inpatient SampleNinth Edition codesImpact of cannabisPoisson regression modelsHospital deathHospital stayIndependent predictorsEdition codesRisk ratioInpatient SampleInternational ClassificationMultivariate analysisPancreatitisPatientsCannabisSignificant increaseRecurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis
Coté GA, Yadav D, Abberbock JA, Whitcomb DC, Sherman S, Sandhu BS, Anderson MA, Lewis MD, Alkaade S, Singh VK, Baillie J, Banks PA, Conwell D, Guda NM, Muniraj T, Tang G, Brand R, Gelrud A, Amann ST, Forsmark CE, Wilcox C, Slivka A, Gardner TB. Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis. The American Journal Of Gastroenterology 2018, 113: 906-912. PMID: 29867178, PMCID: PMC6136830, DOI: 10.1038/s41395-018-0087-7.Peer-Reviewed Original ResearchConceptsMental component summary scoresRecurrent acute pancreatitisLower physical component summaryPhysical component summaryQuality of lifeChronic pancreatitisAcute pancreatitisLower mental component summary scoresMental QOLLower QOLShort Form-12Component summary scoresCross-sectional studyMultivariable regression modelsNon-disease controlsEndocrine insufficiencyComponent summaryIndependent predictorsForm-12CP subjectsPancreatitisSummary scoresObjectivesThe impactU.S. CentersQOL predictorsKnown genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry
Phillips AE, LaRusch J, Greer P, Abberbock J, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Brand RE, Conwell D, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda N, Lewis M, Money ME, Muniraj T, Sandhu BS, Sherman S, Singh VK, Slivka A, Tang G, Wilcox CM, Whitcomb DC, Yadav D. Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry. Pancreatology 2018, 18: 528-535. PMID: 29859674, PMCID: PMC8715541, DOI: 10.1016/j.pan.2018.05.482.Peer-Reviewed Original ResearchPathogenic genetic variantsRecurrent acute pancreatitisAA patientsAA subjectsGenetic variantsAfrican ancestryGenetic susceptibility factorsComplex risk factorsAfrican American subjectsNAPS2 studyAlcohol etiologyAcute pancreatitisChronic pancreatitisEA patientsCP subjectsRisk factorsAA casesPatientsPancreatitisSusceptibility factorsPrevalenceFurther studiesEA subjectsStructured questionnaireSPINK1
2017
Comparative Effectiveness of Pharmacologic and Endoscopic Interventions for the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis: A Network Meta-Analysis
Njei B, McCarty T, Sharma P, Muniraj T, Jamidar P, Aslanian H, Navaneethan U. Comparative Effectiveness of Pharmacologic and Endoscopic Interventions for the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis: A Network Meta-Analysis. The American Journal Of Gastroenterology 2017, 112: s449-s450. DOI: 10.14309/00000434-201710001-00807.Peer-Reviewed Original Research586 Clinical Profile of Early and Late Onset Idiopathic Chronic Pancreatitis (ICP) and the Influence of Known Genetic Factors
Lewis M, Whitcomb D, Talluri J, Abberbock J, Gelrud A, Banks P, Gardner T, Amann S, Sherman S, Sandhu B, Alkaade S, Singh V, Conwell D, Cote G, Guda N, Forsmark C, Wilcox C, Muniraj T, Tang G, Baillie J, Brand R, Slivka A, Anderson M, Yadav D. 586 Clinical Profile of Early and Late Onset Idiopathic Chronic Pancreatitis (ICP) and the Influence of Known Genetic Factors. Gastroenterology 2017, 152: s128. DOI: 10.1016/s0016-5085(17)30760-6.Peer-Reviewed Original ResearchAutoimmune pancreatitis: an update
Muniraj T, Sah R, Chari S. Autoimmune pancreatitis: an update. 2017, 152-160. DOI: 10.1002/9781118924907.ch12d.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsType 1 autoimmune pancreatitisType 2 autoimmune pancreatitisAutoimmune pancreatitisGranulocyte epithelial lesionsAbundant IgG4-positive plasma cellsIgG4-positive plasma cellsLymphoplasmacytic inflammatory infiltrateCommon clinical presentationDistinct histopathologic featuresOral steroidsObstructive jaundiceInflammatory infiltrateInflammatory infiltrationClinical presentationHistopathologic featuresStandard treatmentEpithelial lesionsPancreatic enlargementPlasma cellsDistinct subtypesType 1Concise updatePancreatitisPancreasRemission