2022
Quantifying Mycobacterium tuberculosis Transmission Dynamics Across Global Settings: A Systematic Analysis
Smith J, Cohen T, Dowdy D, Shrestha S, Gandhi NR, Hill AN. Quantifying Mycobacterium tuberculosis Transmission Dynamics Across Global Settings: A Systematic Analysis. American Journal Of Epidemiology 2022, 192: 133-145. PMID: 36227246, PMCID: PMC10144641, DOI: 10.1093/aje/kwac181.Peer-Reviewed Original ResearchConceptsTB transmissionOngoing TB transmissionMinority of casesTuberculosis transmission dynamicsTB controlTuberculosis transmissionSecondary casesSources of heterogeneityInclusion criteriaSurveillance studyTransmission clustersInitial searchTransmission dynamicsWhole-genome sequencingPopulation levelSetting
2021
The positive externalities of migrant-based TB control strategy in a Chinese urban population with internal migration: a transmission-dynamic modeling study
Yang C, Kang J, Lu L, Guo X, Shen X, Cohen T, Menzies NA. The positive externalities of migrant-based TB control strategy in a Chinese urban population with internal migration: a transmission-dynamic modeling study. BMC Medicine 2021, 19: 95. PMID: 33874940, PMCID: PMC8055441, DOI: 10.1186/s12916-021-01968-9.Peer-Reviewed Original ResearchConceptsTB casesTB incidenceNew TB casesTB control strategiesEpidemiology of tuberculosisMeaningful health benefitsChinese urban populationMolecular epidemiologic studiesTransmission dynamic modelSongjiang DistrictRecent infectionTB interventionsTB transmissionTB notificationsEpidemiological featuresPreventive treatmentActive screeningEpidemiologic studiesLatent infectionTB policyDemographic dataIndirect protectionTuberculosisEpidemiological driversLocal transmission
2019
Evaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil
Mabud TS, de Lourdes Delgado Alves M, Ko AI, Basu S, Walter KS, Cohen T, Mathema B, Colijn C, Lemos E, Croda J, Andrews JR. Evaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil. PLOS Medicine 2019, 16: e1002737. PMID: 30677013, PMCID: PMC6345418, DOI: 10.1371/journal.pmed.1002737.Peer-Reviewed Original ResearchConceptsIncidence of TBPrison-based interventionsTB incidenceGeneral populationTB casesCox proportional hazards modelNew TB casesControl of tuberculosisProportional hazards modelPaucity of dataTime of incarcerationTB burdenTB screeningTB riskTB transmissionTB ratesTB epidemicAdministrative databasesCommunity incidenceTuberculosis epidemicHazards modelTB databaseIncidenceEpidemiological contextIntervention
2018
Where is tuberculosis transmission happening? Insights from the literature, new tools to study transmission and implications for the elimination of tuberculosis
Auld SC, Shah NS, Cohen T, Martinson NA, Gandhi NR. Where is tuberculosis transmission happening? Insights from the literature, new tools to study transmission and implications for the elimination of tuberculosis. Respirology 2018, 23: 807-817. PMID: 29869818, PMCID: PMC6281783, DOI: 10.1111/resp.13333.Peer-Reviewed Original ResearchTB control activitiesEvidence-based public health interventionsElimination of tuberculosisBurden of tuberculosisInfection control programCommunity-based transmissionPublic health interventionsCommunity-based settingsUnderstanding of transmissionMiddle-income countriesContact investigationTB incidenceTB transmissionTB epidemicTB strainsTuberculosis transmissionPatterns of transmissionHealth interventionsMeaningful improvementsNew casesMolecular epidemiologyTuberculosisControl activitiesOngoing transmissionVentilation studiesProspects for Tuberculosis Elimination in the United States: Results of a Transmission Dynamic Model
Menzies NA, Cohen T, Hill AN, Yaesoubi R, Galer K, Wolf E, Marks SM, Salomon JA. Prospects for Tuberculosis Elimination in the United States: Results of a Transmission Dynamic Model. American Journal Of Epidemiology 2018, 187: 2011-2020. PMID: 29762657, PMCID: PMC6119121, DOI: 10.1093/aje/kwy094.Peer-Reviewed Original ResearchConceptsTB preventionTB eliminationLatent TB infection (LTBI) screeningTB case detectionHigh-risk populationImportant health benefitsTransmission dynamic modelIncident TBActive TBTuberculosis eliminationInfection testingTB controlTB incidenceEpidemiologic evidenceTB transmissionInfection screeningCase detectionTuberculosis trendsUS populationRisk determinantsHealth benefitsTreatment qualityUnited StatesTreatment activitiesTreatment
2016
Benefits of continuous isoniazid preventive therapy may outweigh resistance risks in a declining tuberculosis/HIV coepidemic
Kunkel A, Crawford FW, Shepherd J, Cohen T. Benefits of continuous isoniazid preventive therapy may outweigh resistance risks in a declining tuberculosis/HIV coepidemic. AIDS 2016, 30: 2715-2723. PMID: 27782966, PMCID: PMC5089846, DOI: 10.1097/qad.0000000000001235.Peer-Reviewed Original ResearchConceptsContinuous isoniazid preventive therapyIsoniazid preventive therapyIsoniazid-resistant tuberculosisTB epidemicPreventive therapyEffective TB treatmentLatent TB infectionTB drug resistanceTransmission dynamic modelTB infectionMortality benefitTB treatmentHIV controlHIV incidenceTB incidenceTB transmissionCase findingDrug resistanceIncidenceTuberculosisInitial benefitPLHIVHIVTherapyEpidemic
2013
Identifying dynamic tuberculosis case-finding policies for HIV/TB coepidemics
Yaesoubi R, Cohen T. Identifying dynamic tuberculosis case-finding policies for HIV/TB coepidemics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 9457-9462. PMID: 23690585, PMCID: PMC3677479, DOI: 10.1073/pnas.1218770110.Peer-Reviewed Original ResearchConceptsUndiagnosed casesHigh-burden settingsSmear-negative casesTB control programsDuration of roundsBurden settingsTB suspectsTB transmissionAggressive approachOnward transmissionIncremental yieldPopulation healthIncremental benefitInfectious individualsDiagnostic toolControl programsICFPassive caseSymptomsCasesSettingDiagnosis
2006
Exogenous re-infection and the dynamics of tuberculosis epidemics: local effects in a network model of transmission
Cohen T, Colijn C, Finklea B, Murray M. Exogenous re-infection and the dynamics of tuberculosis epidemics: local effects in a network model of transmission. Journal Of The Royal Society Interface 2006, 4: 523-531. PMID: 17251134, PMCID: PMC2373405, DOI: 10.1098/rsif.2006.0193.Peer-Reviewed Original ResearchConceptsTB control strategiesPublic health policy makersType of TBMolecular epidemiologic toolsHealth policy makersTB diseasePrimary diseasePrimary progressionTB incidenceRecent infectionTB transmissionTuberculosis diseaseInfectious disease transmissionTuberculosis epidemicRecent transmissionEpidemiological dataForce of infectionInfectious casesLatent infectionEpidemiologic toolInfectionMycobacterium tuberculosisSpecific populationsDiseaseEpidemic trajectories