2010
The Prevalence and Drug Sensitivity of Tuberculosis among Patients Dying in Hospital in KwaZulu-Natal, South Africa: A Postmortem Study
Cohen T, Murray M, Wallengren K, Alvarez GG, Samuel EY, Wilson D. The Prevalence and Drug Sensitivity of Tuberculosis among Patients Dying in Hospital in KwaZulu-Natal, South Africa: A Postmortem Study. PLOS Medicine 2010, 7: e1000296. PMID: 20582324, PMCID: PMC2889914, DOI: 10.1371/journal.pmed.1000296.Peer-Reviewed Original ResearchConceptsTime of deathTuberculosis treatmentLimited autopsiesM. tuberculosisMultidrug-resistant bacilliCulture-positive tuberculosisInitiation of treatmentMultidrug-resistant tuberculosisHIV-positive individualsMajority of decedentsRespiratory tract secretionsHigh HIV prevalenceSecond-line antibioticsNeedle core biopsySingle public hospitalDiagnosis of tuberculosisAcid-fast bacilliCause of deathNew public health approachPublic health approachMagnitude of deathsFatal courseAdult inpatientsStudy cohortHIV prevalence
2008
Are Survey-Based Estimates of the Burden of Drug Resistant TB Too Low? Insight from a Simulation Study
Cohen T, Colijn C, Finklea B, Wright A, Zignol M, Pym A, Murray M. Are Survey-Based Estimates of the Burden of Drug Resistant TB Too Low? Insight from a Simulation Study. PLOS ONE 2008, 3: e2363. PMID: 18523659, PMCID: PMC2408555, DOI: 10.1371/journal.pone.0002363.Peer-Reviewed Original ResearchConceptsResistant tuberculosisIncident casesTotal burdenDrug-resistant TBDrug-resistant tuberculosisSecond-line antibioticsDrug treatment regimensDrug sensitivity testingDrug-resistant strainsBurden of resistanceEmergence of tuberculosisResistant TBTreatment regimensPrevalent casesWorldwide burdenIntroduction of interventionsRoutine surveillanceSurveillance strategiesDrug resistanceTuberculosisLaboratory capacityMycobacterium tuberculosisSensitivity testingTuberculosis modelBurden