2017
Tumor Emboli: A Rare Cause of Acute Pulmonary Hypertension
Mainardi A, Trow T. Tumor Emboli: A Rare Cause of Acute Pulmonary Hypertension. The American Journal Of Medicine 2017, 130: e137-e139. PMID: 28159185, DOI: 10.1016/j.amjmed.2016.11.023.Peer-Reviewed Original Research
2014
Pharmacologic Therapy for Pulmonary Arterial Hypertension in Adults CHEST Guideline and Expert Panel Report
Taichman DB, Ornelas J, Chung L, Klinger JR, Lewis S, Mandel J, Palevsky HI, Rich S, Sood N, Rosenzweig EB, Trow TK, Yung R, Elliott CG, Badesch DB. Pharmacologic Therapy for Pulmonary Arterial Hypertension in Adults CHEST Guideline and Expert Panel Report. CHEST Journal 2014, 146: 449-475. PMID: 24937180, PMCID: PMC4137591, DOI: 10.1378/chest.14-0793.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionHigh-level evidenceConsensus statementPharmacologic therapyAvailable evidenceArterial hypertensionGrades of RecommendationCochrane Library databasesExpert Panel ReportClinician adviceOptimal pharmacotherapyAdult patientsCHEST GuidelineGuideline recommendationsHigh-level recommendationsClinical questionsLibrary databasesSystematic reviewClinical decisionPharmacotherapyTherapyHypertensionEnglish-language evidenceLevel evidenceFurther studiesUnresolved pulmonary embolism leading to a diagnosis of pulmonary artery sarcoma
Gutiérrez A, Sauler M, Mitchell JM, Siegel MD, Trow TK, Bacchetta M, Fares WH. Unresolved pulmonary embolism leading to a diagnosis of pulmonary artery sarcoma. Heart & Lung 2014, 43: 574-576. PMID: 24928184, DOI: 10.1016/j.hrtlng.2014.05.006.Peer-Reviewed Case Reports and Technical NotesConceptsPulmonary artery sarcomaPulmonary embolismPresumed pulmonary embolismUnresolved pulmonary embolismCT pulmonary angiogramAnticoagulation treatmentProgressive symptomsPulmonary angiogramSurgical resectionPulmonary arteryPoor prognosisRare tumorAdditional imagingDifferential diagnosisProper diagnosisEmbolismSarcomaDiagnosisResectionPatientsDyspneaArteryPrognosisAngiogramsMetastasis
2013
Preface
Trow TK. Preface. Clinics In Chest Medicine 2013, 34: xiii-xiv. PMID: 24267311, DOI: 10.1016/j.ccm.2013.10.009.Peer-Reviewed Original ResearchDiagnosis of Pulmonary Arterial Hypertension
Forfia PR, Trow TK. Diagnosis of Pulmonary Arterial Hypertension. Clinics In Chest Medicine 2013, 34: 665-681. PMID: 24267297, DOI: 10.1016/j.ccm.2013.09.001.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionArterial hypertensionPulmonary venous hypertensionPopulation of patientsEchocardiographic cluesNonpharmacologic managementPulmonary hypertensionRight shuntingVenous hypertensionCardiac catheterizationClinical suspicionRight heartNoninvasive testsPhysical examLeft heartHigh indexHypertensionAccurate diagnosisDiagnosisCareful assessmentCatheterizationHeartPatientsShuntingSuspicionStandard Nonspecific Therapies in the Management of Pulmonary Arterial Hypertension
Sauler M, Fares WH, Trow TK. Standard Nonspecific Therapies in the Management of Pulmonary Arterial Hypertension. Clinics In Chest Medicine 2013, 34: 799-810. PMID: 24267305, DOI: 10.1016/j.ccm.2013.08.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHigh-dose calcium channel blockersCommon cardiopulmonary diseasesPAH-specific therapyPulmonary arterial hypertensionTreatment of patientsCalcium channel blockersPAH therapyArterial hypertensionAdjunct therapyOxygen therapyMedical therapyNonspecific therapyCardiopulmonary diseasePathologic understandingChannel blockersSmall studyTherapyHypertension researchExpert opinionAnticoagulationHypertensionDiureticsPatientsBlockersDigoxin
2012
IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension
Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG. IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2012, 304: l112-l124. PMID: 23125252, PMCID: PMC3543640, DOI: 10.1152/ajplung.00101.2012.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionIL-13Human pulmonary artery smooth muscle cellsDevelopment of PHPulmonary artery smooth muscle cellsRight ventricle systolic pressurePathogenesis of PHArtery smooth muscle cellsExpression of ARG2Pulmonary arterial hypertensionPulmonary vascular remodelingVentricle systolic pressurePotential therapeutic targetIL-13 treatmentSmooth muscle cellsNull mutant miceArterial hypertensionEffector cytokinesMedial thickeningSystolic pressureHemodynamic changesPulmonary arterySmall-interfering RNAVascular remodelingArginase-2Targeted approaches to the treatment of pulmonary hypertension
Fares WH, Trow TK. Targeted approaches to the treatment of pulmonary hypertension. Therapeutic Advances In Respiratory Disease 2012, 6: 147-159. PMID: 22438264, DOI: 10.1177/1753465812441849.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionArterial hypertensionHigh-dose calcium channel blockersChest Physicians criteriaMultiple therapeutic optionsDurability of responseCalcium channel blockersTransplant evaluationPulmonary hypertensionOral therapyClose followPhysician's criteriaTherapeutic optionsChannel blockersEarly initiationAmerican CollegeHigh riskPatientsIncurable diseaseHypertensionEarly useStatus benefitsTreatmentDiseaseProgression
2011
Pregnancy and Pulmonary Hypertension
Lane CR, Trow TK. Pregnancy and Pulmonary Hypertension. Clinics In Chest Medicine 2011, 32: 165-174. PMID: 21277457, DOI: 10.1016/j.ccm.2010.10.006.Peer-Reviewed Original ResearchReproducibility of Oxygen Saturation Monitoring During Six-Minute Walk Test and Exercise Stress Test in Patients with Pulmonary Arteriovenous Malformations Associated With Hereditary Hemorrhagic Telangiectasia
Li W, Niu B, Henderson K, Northrup V, Pollak JS, Trow T, Fahey J, White RI. Reproducibility of Oxygen Saturation Monitoring During Six-Minute Walk Test and Exercise Stress Test in Patients with Pulmonary Arteriovenous Malformations Associated With Hereditary Hemorrhagic Telangiectasia. Pediatric Cardiology 2011, 32: 590-594. PMID: 21336824, DOI: 10.1007/s00246-011-9917-8.Peer-Reviewed Original ResearchConceptsPulmonary arteriovenous malformationsHereditary hemorrhagic telangiectasiaOxygen saturationHeart rateWalk testArteriovenous malformationsHemorrhagic telangiectasiaSix-minute walk testOxygen saturation monitoringLowest oxygen saturationYears of ageHuman Investigation CommitteeStress testIntraclass correlation coefficientAnatomic subtypesExercise capacityMultiple complicationsPatientsAdjunct testSaturation monitoringAdequate restReproducible measureMalformationsTelangiectasiaBroad spectrum
2010
Chronic Thromboembolic Pulmonary Hypertension
Auger WR, Kim NH, Trow TK. Chronic Thromboembolic Pulmonary Hypertension. Clinics In Chest Medicine 2010, 31: 741-758. PMID: 21047580, DOI: 10.1016/j.ccm.2010.07.006.Peer-Reviewed Original ResearchConceptsChronic thromboembolic pulmonary hypertensionThromboembolic pulmonary hypertensionPulmonary hypertensionSpecific medical therapySmall vessel arteriopathyMedical therapyPreoperative evaluationMechanical obstructionPulmonary vasculatureAcute embolusRisk factorsHypertensionPatientsNatural historyPutative mechanismsLimited dataSole causeArteriopathyEndartectomyEmboliObstructionTherapyNoncandidatesEpidemiologyDiagnosisA 71-Year-Old Woman With Myelofibrosis, Hypoxemia, and Pulmonary Hypertension
Trow TK, Argento AC, Rubinowitz AN, Decker R. A 71-Year-Old Woman With Myelofibrosis, Hypoxemia, and Pulmonary Hypertension. CHEST Journal 2010, 138: 1506-1510. PMID: 21138888, DOI: 10.1378/chest.10-0973.Peer-Reviewed Original ResearchAgedAntimonyBiopsy, NeedleBlood Chemical AnalysisCardiac CatheterizationDiagnosis, DifferentialDyspneaFemaleHematopoiesis, ExtramedullaryHumansHypertension, PulmonaryHypoxiaImmunohistochemistryLung DiseasesPhysical ExaminationPrimary MyelofibrosisRadionuclide ImagingRare DiseasesRespiratory Function TestsTechnetium CompoundsTomography, X-Ray Computed
2009
Granulomatous bronchiolitis of Crohn’s disease successfully treated with inhaled budesonide
Trow TK, Morris DG, Miller CR, Homer RJ. Granulomatous bronchiolitis of Crohn’s disease successfully treated with inhaled budesonide. Thorax 2009, 64: 546. PMID: 19478123, DOI: 10.1136/thx.2008.107185.Peer-Reviewed Original ResearchEndothelin receptor blockade in the management of pulmonary arterial hypertension: Selective and dual antagonism
Trow TK, Taichman DB. Endothelin receptor blockade in the management of pulmonary arterial hypertension: Selective and dual antagonism. Respiratory Medicine 2009, 103: 951-962. PMID: 19304472, DOI: 10.1016/j.rmed.2009.02.016.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionEndothelin receptor antagonistsArterial hypertensionET-1Development of PAHManagement of PAHPathogenesis of PAHEndothelin receptor blockadeLiver function abnormalitiesPlacebo-controlled trialNitric oxide-mediated pathwayClinical study resultsGood clinical resultsClinical treatment studiesUnited States FoodPeripheral edemaFunction abnormalitiesReceptor blockadeDual antagonismDual blockadeSafety profileET receptorsEndothelin-1Head studiesReceptor antagonistPulmonary Hypertension. In Lang F, editor, Encyclopedia of Molecular Mechanisms of Disease.
Trow TK, McLauglin VV. Pulmonary Hypertension. In Lang F, editor, Encyclopedia of Molecular Mechanisms of Disease. 1st edition, Heidelberg: Spring-Verlag; 2009. pp 1771-1773.Peer-Reviewed Original Research
2008
Pulmonary Hypertension After Surgical Laminectomy: An Easily Missed Cause of a High-Output State
Curran DR, Trow TK, Muhs B, Sergi M. Pulmonary Hypertension After Surgical Laminectomy: An Easily Missed Cause of a High-Output State. The American Journal Of Medicine 2008, 121: e3-e4. PMID: 18691468, DOI: 10.1016/j.amjmed.2008.03.044.Peer-Reviewed Original Research
2007
Introduction
Trow T. Introduction. Annals Of The American Thoracic Society 2007, 4: 477-477. DOI: 10.1513/pats.200707-112tt.Peer-Reviewed Original ResearchCombination Therapy in the Treatment of Pulmonary Arterial Hypertension: Can That Dog Hunt?
Cho W, Trow T. Combination Therapy in the Treatment of Pulmonary Arterial Hypertension: Can That Dog Hunt? Clinical Pulmonary Medicine 2007, 14: 242-243. DOI: 10.1097/cpm.0b013e3180cac712.Peer-Reviewed Original ResearchPulmonary Hypertension in the Elderly: More Common Than We Thought?
Mannam P, Trow T. Pulmonary Hypertension in the Elderly: More Common Than We Thought? Clinical Pulmonary Medicine 2007, 14: 240-242. DOI: 10.1097/cpm.0b013e3180cac701.Peer-Reviewed Original Research
2006
Radiology–Pathology Conference: sclerosing hemangioma of the lung
Neuman J, Rosioreanu A, Schuss A, Turi G, Yung E, Trow TK, Williams L, Katz DS. Radiology–Pathology Conference: sclerosing hemangioma of the lung. Clinical Imaging 2006, 30: 409-412. PMID: 17101410, DOI: 10.1016/j.clinimag.2006.05.030.Peer-Reviewed Original ResearchConceptsFluorodeoxyglucose positron emission tomography (FDG-PET) findingsPositron emission tomography findingsCharacteristic imaging findingsDefinitive diagnostic testTomography findingsImaging findingsUnusual tumorBenign neoplasmsDiagnostic testsHemangiomaLungPatientsBiopsyNeoplasmsTumorsFindingsPathology