Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea.
Cortese R, Adams T, Cataldo K, Hummel J, Kaminski N, Kheirandish-Gozal L, Gozal D. Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea. European Respiratory Journal 2022, 61: 2201465. PMID: 36356973, DOI: 10.1183/13993003.01465-2022.Peer-Reviewed Original ResearchConceptsObstructive sleep apnoeaSleep apnoeaImpact of OSASystemic immune functionMononuclear cell compositionMolecular signaturesCell-specific markersSystemic inflammationCardiovascular dysfunctionImmune cellsImmune functionSingle-cell transcriptomic analysisPaediatric sleep apnoeaUndescribed cell typePrevalent diseaseMajor causeCellular compositionApnoeaCell compositionRNA expression datasetsDiagnostic settingCell typesCell lineagesMolecular diagnostic settingScRNA-seqSingle-Cell RNAseq Reveals Cell Composition and Gene Expression Patterns in the Peripheral Blood of Pediatric Obstructive Sleep Apnea
Cortese R, Adams T, Hohensee K, Kaminski N, Gozal L, Gozal D. Single-Cell RNAseq Reveals Cell Composition and Gene Expression Patterns in the Peripheral Blood of Pediatric Obstructive Sleep Apnea. 2022, a2565-a2565. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2565.Peer-Reviewed Original Research