2022
Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma
Kim A, Choi S, Park J, Kwon M, Chowdhury T, Yu H, Kim S, Kang H, Kim K, Park S, Park C, Shin E. Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma. OncoImmunology 2022, 11: 2026019. PMID: 35036078, PMCID: PMC8757477, DOI: 10.1080/2162402x.2022.2026019.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasTumor immune microenvironmentTumor-associated macrophagesM2 tumor-associated macrophagesT cellsExhausted CD8Immune cellsImmunosuppressive cellsCTLA-4Hypoxic conditionsImmunosuppressive tumor immune microenvironmentProgression-free survivalRegulatory T cellsSurvival of patientsImmunosuppressive profilePD-1Patient survivalImmune microenvironmentImmune heterogeneityHypoxia signatureCD8Different biological featuresPatientsFlow cytometrySurvival
2020
Penta-fluorophenol: a Smiles rearrangement-inspired cysteine-selective fluorescent probe for imaging of human glioblastoma
An J, Kang S, Huh E, Kim Y, Lee D, Jo H, Joung J, Kim V, Lee J, Dho Y, Jung Y, Hur J, Park C, Jung J, Huh Y, Ku J, Kim S, Chowdhury T, Park S, Kang J, Oh M, Park C, Kim D. Penta-fluorophenol: a Smiles rearrangement-inspired cysteine-selective fluorescent probe for imaging of human glioblastoma. Chemical Science 2020, 11: 5658-5668. PMID: 32874505, PMCID: PMC7449700, DOI: 10.1039/d0sc01085e.Peer-Reviewed Original ResearchLong-term toxicitySpecific diagnostic proceduresClinical biopsy samplesHuman-derived cellsImmune responseIndividual patientsMouse modelGlioblastoma patientsBiopsy samplesNew biomarkersClinical sitesDisease sitesHuman tissue samplesDiagnostic proceduresGBM cellsHuman glioblastomaTreatment progressTissue samplesClinical samplesCysteine levelsPatientsPrecision diagnosisPresent findingsGBMImaging