Efficacy of orexin antagonists for the management of major depressive disorder: A systematic review of randomized clinical trials
Meshkat S, Kwan A, Le G, Wong S, Teopiz K, Wang L, Rosenblat J, Rhee T, Cao B, McIntyre R. Efficacy of orexin antagonists for the management of major depressive disorder: A systematic review of randomized clinical trials. Journal Of Affective Disorders 2024 PMID: 39638064, DOI: 10.1016/j.jad.2024.12.008.Peer-Reviewed Original ResearchOrexin receptor antagonistsHamilton Depression Rating ScaleDepression Rating ScaleDepressive disorderQuick Inventory of Depressive Symptomatology Self-ReportReceptor antagonistInventory of Depressive Symptomatology Self-ReportDepressive symptoms compared to placeboMontgomery-Asberg Depression Rating ScaleRating ScaleDepressive Symptomatology Self-ReportMADRS total scoreSymptoms compared to placeboTreatment of depressionDecreased depression scoresQIDS-SRMDD patientsMontgomery-AsbergManaging depressive symptomsRandomized clinical trialsOrexin antagonistsDepression treatmentDepressive symptomsTreating insomniaCompared to placebo