2023
Human TRPV1 structure and inhibition by the analgesic SB-366791
Neuberger A, Oda M, Nikolaev Y, Nadezhdin K, Gracheva E, Bagriantsev S, Sobolevsky A. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nature Communications 2023, 14: 2451. PMID: 37117175, PMCID: PMC10147690, DOI: 10.1038/s41467-023-38162-9.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsCryoelectron MicroscopyHumansPainTransient Receptor Potential ChannelsTRPV Cation ChannelsConceptsSB-366791Transient receptor potential (TRP) ion channelsPotential ion channelsPain pathwaysPain therapyPain treatmentPsychiatric disordersOpioid crisisTherapy targetTRPV1 inhibitorElectrophysiological recordingsHuman TRPV1TRP channelsTRPV1New drugsDisease conditionsVanilloid subfamilyIon channelsTreatmentInhibitorsOpioidsPainTherapyDiseaseCryo-electron microscopy structure
2016
Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels
Laursen WJ, Schneider ER, Merriman DK, Bagriantsev SN, Gracheva EO. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 11342-11347. PMID: 27638213, PMCID: PMC5056056, DOI: 10.1073/pnas.1604269113.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAmino Acid SequenceAmino Acid SubstitutionAnimalsAnkyrin RepeatCamelusCapsaicinConserved SequenceGanglia, SpinalHEK293 CellsHot TemperatureHumansHydrogen-Ion ConcentrationIon Channel GatingMutationNeuronsSciuridaeSequence AlignmentThermotoleranceTRPV Cation ChannelsXenopusConceptsHeat toleranceCommon molecular strategyN-terminal ankyrinSingle amino acid changeSingle amino acid substitutionGround squirrelsPolymodal ion channelAmino acid changesAmino acid substitutionsRemarkable functional flexibilityFunctional conservationEcological nichesChemical cuesMammalian speciesMolecular strategiesAcid changesAcid substitutionsHeat sensitivityTransient receptor potential vanilloid 1Ion channelsOrthologsFunctional plasticitySquirrelsBactrian camelsSuch adaptation
2014
Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl
Schneider ER, Mastrotto M, Laursen WJ, Schulz VP, Goodman JB, Funk OH, Gallagher PG, Gracheva EO, Bagriantsev SN. Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 14941-14946. PMID: 25246547, PMCID: PMC4205607, DOI: 10.1073/pnas.1413656111.Peer-Reviewed Original ResearchConceptsTrigeminal ganglionIon channel Piezo2Light mechanical stimuliMechanoreceptive neuronsTG neuronsPrimary afferentsMechanical stimuliTrigeminal afferentsNeuronal excitationEnd organsNeuronal mechanismsDirect mechanical stimulationCellular mechanismsMechanical stimulationAfferentsNeuronsLow thresholdNumerical expansionGangliaStimuli