2020
Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets
Achanta S, Jordt S. Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. Annals Of The New York Academy Of Sciences 2020, 1480: 73-103. PMID: 32892378, PMCID: PMC7933981, DOI: 10.1111/nyas.14472.Peer-Reviewed Original ResearchConceptsChemical injuryTRP channelsNeurogenic inflammatory pathwaysChemical threat agentsMediator of injuryTransient receptor potential channelsTransient receptor potential (TRP) ion channelsIntracellular calcium levelsToxic inhalation hazardPotential ion channelsCough reflexPulmonary injuryPulmonary edemaProinflammatory cellsInflammatory pathwaysPathophysiologic eventsOccupational exposureMucus clearanceCalcium levelsInjuryNonneuronal pathwaysRespiratory systemBroader indicationsPotential channelsInhalation hazard
2013
TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis
Liu B, Escalera J, Balakrishna S, Fan L, Caceres A, Robinson E, Sui A, McKay M, McAlexander M, Herrick C, Jordt S. TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. The FASEB Journal 2013, 27: 3549-3563. PMID: 23722916, PMCID: PMC3752543, DOI: 10.1096/fj.13-229948.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisSubstance PScratching behaviorContact dermatitisSensory neuronsSP receptor antagonistTRPA1-deficient miceCommon skin diseaseChronic inflammatory responseTransient receptor potential (TRP) ion channelsNerve growth factorPotential ion channelsEndogenous pruritogensPruritic responsesPersistent pruritusCutaneous inflammationLeukocyte infiltrationInflammatory cytokinesSkin edemaReceptor antagonistAllergic responsesContact allergensInflammatory responseKeratinocyte hyperplasiaSP signaling