2024
Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice
Wu P, Caceres A, Chen J, Sokoloff J, Huang M, Baht G, Nackley A, Jordt S, Terrando N. Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice. Pain 2024, 165: e80-e92. PMID: 38422485, PMCID: PMC11247455, DOI: 10.1097/j.pain.0000000000003181.Peer-Reviewed Original ResearchDorsal root gangliaPostoperative painVagus nerve stimulationPain behaviorOrthopedic surgeryNerve stimulationHindpaw mechanical allodyniaPrevent postoperative painFemale C57BL/6J miceOrthopedic trauma surgeryMechanical allodyniaAntinociceptive effectPersistent painAccelerated bone healingAnalgesic effectAdult miceC57BL/6J miceEffective therapyNeuropeptide levelsSpinal cordMouse modelSatellite cellsSurgeryPainVagus nerve
2023
Effect Of Comt Genetic Background And Stress On Pain Following Tibial Fracture
Chen J, Wu Y, Wang Y, Sandu C, Gu E, Jordt S, Terrando N, Nackley A. Effect Of Comt Genetic Background And Stress On Pain Following Tibial Fracture. Journal Of Pain 2023, 24: 30. DOI: 10.1016/j.jpain.2023.02.098.Peer-Reviewed Original ResearchDepressive-like behaviorStress fracture groupTail suspension testTibial fracturesSham stressAbdominal sitesSuspension testSham–sham groupVon Frey filamentsWild-type miceAbdominal hyperalgesiaMechanical hyperalgesiaMechanical hypersensitivityImmobility timeWT miceBody painType miceHyperalgesiaPainSpinal needleActivity genotypeMonth time periodGenetic inhibitionStress groupCOMT genotype
2006
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents. Cell 2006, 124: 1269-1282. PMID: 16564016, DOI: 10.1016/j.cell.2006.02.023.Peer-Reviewed Original ResearchConceptsTRPA1-deficient miceInflammatory painEnvironmental irritantsInflammatory actionsProalgesic agentsPrimary afferent nociceptorsExcitatory ion channelPain hypersensitivityPungent irritantsAfferent nociceptorsNociceptor excitationAuditory functionThermal nociceptionNoxious coldMice exhibitChemotherapeutic agentsTRPA1PainIrritantsNociceptorsMiceSole targetMustard oilIon channelsInitial detection
2005
Pungent products from garlic activate the sensory ion channel TRPA1
Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM. Pungent products from garlic activate the sensory ion channel TRPA1. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 12248-12252. PMID: 16103371, PMCID: PMC1189336, DOI: 10.1073/pnas.0505356102.Peer-Reviewed Original ResearchConceptsSensory nerve endingsSensory neuronsNerve endingsTRPA1 channelsDiallyl disulfidePrimary sensory neuronsActivation of TRPA1Ion channel TRPA1Excitatory ion channelPain pathwaysPungent ingredientAllium familyVasorelaxant activityTRPA1Health benefitsNeuronsAllium extractsIon channelsAllicinMolecular mechanismsAllyl isothiocyanateEndingsPainVasodilationInflammation
2004
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004, 427: 260-265. PMID: 14712238, DOI: 10.1038/nature02282.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnkyrinsCalcium ChannelsCalcium SignalingCannabinoidsCapsaicinCarbacholCells, CulturedCloning, MolecularDronabinolHumansMustard PlantNerve Tissue ProteinsNeurons, AfferentNociceptorsOocytesPlant OilsRatsRats, Sprague-DawleyRNA, MessengerThapsigarginTransient Receptor Potential ChannelsTrigeminal GanglionTRPA1 Cation ChannelTRPC Cation ChannelsConceptsMustard oilPrimary sensory neuronsSensory nerve fibersSensory nerve endingsTRP ion channel familyExcitatory effectsNerve endingsNerve fibersIon channel familyPungent ingredientSensory neuronsTopical applicationPsychoactive componentΔ9-tetrahydrocannabinolTRP channelsMolecular targetsANKTM1Channel familyMolecular mechanismsAllyl isothiocyanatePainInflammationWidespread useCapsaicinHypersensitivity