A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-9104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.Peer-Reviewed Original ResearchConceptsAsthmatic airway inflammationAirway inflammationAirway hyperreactivityAllergen challengeHC-030031Airway allergen challengeEndogenous TRPA1 agonistsMurine ovalbumin modelImpaired inflammatory responseTreatment of asthmaRole of TRPA1Wild-type miceAirway epithelial functionAllergic inflammatory conditionsPromising pharmacological targetNeuronal ion channelsLipid peroxidation productsIon channelsAllergic asthmaAirway exposureEosinophil infiltrationLeukocyte infiltrationContractile stimuliInflammatory disordersOvalbumin modelDecreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1
Caceres A, Brackmann M, Bessac B, Cohn L, Jordt S. Decreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1. The FASEB Journal 2009, 23: 580.10-580.10. DOI: 10.1096/fasebj.23.1_supplement.580.10.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseAirway inflammationOvalbumin-induced airway inflammationOvalbumin mouse modelAllergic airway inflammationObstructive pulmonary diseaseTRPA1-deficient miceChronic inflammatory statePeripheral sensory neuronsBronchoalveolar lavage fluidPro-inflammatory peptidesTh2-derived cytokinesIon channel TRPA1Lipid peroxidation productsAirway conditionsEosinophil infiltrationInflammatory mediatorsPulmonary diseaseNeuronal releaseAirway constrictionInflammatory stateLavage fluidVascular leakageEdema formationInflammatory process