2023
Vagus Nerve Stimulation Rescues Persistent Pain Following Orthopedic Surgery In Adult Mice
Wu P, De Caceres A, Baht G, Terrando N, Jordt S. Vagus Nerve Stimulation Rescues Persistent Pain Following Orthopedic Surgery In Adult Mice. Journal Of Pain 2023, 24: 10. DOI: 10.1016/j.jpain.2023.02.044.Peer-Reviewed Original ResearchVagus nerve stimulationPostoperative painOrthopedic surgeryNerve stimulationPain 2 yearsAnti-nociceptive effectsPersistent postoperative painSatellite glial cellsAnti-inflammatory effectsMajor clinical problemBilateral hindTibial surgeryMicroglia activationRisk patientsPain sensitizationPersistent painVagus nervePain behaviorEffective therapyFemale miceSpinal cordWeekly treatmentGlial cellsGFAP expressionInvasive procedures
2017
Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti‐inflammatory effects of eucalyptol
Caceres AI, Liu B, Jabba SV, Achanta S, Morris JB, Jordt S. Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti‐inflammatory effects of eucalyptol. British Journal Of Pharmacology 2017, 174: 867-879. PMID: 28240768, PMCID: PMC5387001, DOI: 10.1111/bph.13760.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Infective AgentsAnti-Inflammatory AgentsCyclohexanolsDose-Response Relationship, DrugEdemaEucalyptolFemaleHEK293 CellsHumansInflammationInflammation MediatorsMaleMiceMice, Inbred C57BLMice, KnockoutMonoterpenesRandom AllocationTransient Receptor Potential ChannelsTRPM Cation ChannelsConceptsAnti-inflammatory effectsComplete Freund's adjuvantTRPM8 channelsPulmonary inflammationLeukocyte infiltrationNovel anti-inflammatory agentsInflammatory pain responsesSelective TRPM8 agonistsAdministration of LPSAnti-inflammatory propertiesChannel-deficient miceAnti-inflammatory agentsEffect of eucalyptolProduction of TNFTRP cation channelsMechanical allodyniaChemokine levelsTRPM8 agonistMyeloperoxidase activityFootpad inflammationFreund's adjuvantPain responseIL-1βIL-6Inflammatory cytokines
2016
The anti-inflammatory effects of eucalyptol in a mouse model of LPS-induced pulmonary inflammation are mediated by TRPM8
de Caceres Bustos A, Liu B, Jabba S, Morris J, Jordt S. The anti-inflammatory effects of eucalyptol in a mouse model of LPS-induced pulmonary inflammation are mediated by TRPM8. 2016, oa4541. DOI: 10.1183/13993003.congress-2016.oa4541.Peer-Reviewed Original Research