2023
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression
Wei J, Alfajaro M, Cai W, Graziano V, Strine M, Filler R, Biering S, Sarnik S, Patel S, Menasche B, Compton S, Konermann S, Hsu P, Orchard R, Yan Q, Wilen C. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression. PLOS Pathogens 2023, 19: e1011351. PMID: 37410700, PMCID: PMC10325096, DOI: 10.1371/journal.ppat.1011351.Peer-Reviewed Original ResearchConceptsMouse hepatitis virusReceptor expressionTherapeutic targetMERS-CoVMajor SARS-CoV-2 variantsPrimary human airwaySARS-CoV-2 variantsNovel therapeutic targetViral receptor expressionSARS-CoV-2Histone methyltransferase KMT2DIntestinal epithelial cellsCoronavirus SusceptibilityDiverse coronavirusesHistone demethylase KDM6ADPP4 expressionCoronavirus receptorsHost determinantsHepatitis virusHuman airwaysSARS-CoVSmall molecule inhibitionViral entryPotential drug targetsViral receptors
2021
Overview of Coronaviruses in Veterinary Medicine.
Compton SR. Overview of Coronaviruses in Veterinary Medicine. Comparative Medicine 2021, 71: 333-341. PMID: 34412731, PMCID: PMC8594256, DOI: 10.30802/aalas-cm-21-000007.Peer-Reviewed Original ResearchAnimal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis
Zeiss CJ, Compton S, Veenhuis RT. Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis. ILAR Journal 2021, 62: ilab007-. PMID: 33836527, PMCID: PMC8083356, DOI: 10.1093/ilar/ilab007.Peer-Reviewed Original ResearchConceptsSARS-CoV-2SARS-CoVViral sheddingImmune responseSpontaneous modelAnimal modelsDisease pathogenesisSARS-CoV-2 infectionCOVID-19Severe acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusChimeric SARS-CoVRole of comorbiditiesCoronavirus disease 2019 (COVID-19) pandemicShort-term immune responseWild-type miceSeverity of diseaseOrgan-specific pathologySARS-CoV-2 virusDisease 2019 pandemicAfrican green monkeysTest therapeuticsVaccine approachesNonfatal diseaseTissue involvement
2017
Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice.
Compton SR, Booth CJ, Macy JD. Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice. Comparative Medicine 2017, 67: 400-406. PMID: 28935001, PMCID: PMC5621567.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstroviridaeAstroviridae InfectionsColitisColonDextran SulfateDisease Models, AnimalFemaleGastrointestinal MicrobiomeInflammasomesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinRandom AllocationReal-Time Polymerase Chain ReactionReproducibility of ResultsRodent DiseasesRodentiaConceptsColitis modelInflammatory bowel disease researchNOD-like receptor 3Induced colitis modelSeverity of colitisDextran sodium sulfateDSS colitis modelNLRP3-deficient miceDefective inflammasome activationLack of effectMucosal ulcerationIntestinal inflammationHistopathologic changesIntestinal permeabilityAstrovirus infectionFemale miceClinical signsDeficient miceNLRP3 mutationsClinical diseaseInflammasome activationGastrointestinal tractMurine astrovirusIntestinal bacteriaIntestinal epitheliumMurine Astrovirus Infection and Transmission in Neonatal CD1 Mice.
Compton SR, Booth CJ, Macy JD. Murine Astrovirus Infection and Transmission in Neonatal CD1 Mice. Journal Of The American Association For Laboratory Animal Science 2017, 56: 402-411. PMID: 28724490, PMCID: PMC5517330.Peer-Reviewed Original Research
2015
Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis.
Compton SR, Macy JD. Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis. Journal Of The American Association For Laboratory Animal Science 2015, 54: 745-55. PMID: 26632784, PMCID: PMC4671790.Peer-Reviewed Original ResearchConceptsMouse hepatitis virusMouse parvovirusMyocoptes musculinusInfectious agentsS. obvelataDetection of infectionHepatitis virusPCR analysisHousing micePathogen transmissionFacility levelMiceCages housing miceHelicobacter sppM. pulmonisSyphacia obvelataMycoplasma pulmonisCage washingParvovirusAnimal facilitiesSentinelsVirusAgentsPulmonisPathogen screening
2013
Effect of immunodeficiency on MPV shedding and transmission.
Macy JD, Paturzo FX, Compton SR. Effect of immunodeficiency on MPV shedding and transmission. Journal Of The American Association For Laboratory Animal Science 2013, 52: 467-74. PMID: 23849445, PMCID: PMC3725932.Peer-Reviewed Original Research
2012
Transmission of mouse parvovirus to neonatal mice.
Compton SR, Paturzo FX, Macy JD. Transmission of mouse parvovirus to neonatal mice. Journal Of The American Association For Laboratory Animal Science 2012, 51: 797-802. PMID: 23294886, PMCID: PMC3508184.Peer-Reviewed Original ResearchAge-associated variability in susceptibility of Swiss Webster mice to MPV and other excluded murine pathogens.
Grove KA, Smith PC, Booth CJ, Compton SR. Age-associated variability in susceptibility of Swiss Webster mice to MPV and other excluded murine pathogens. Journal Of The American Association For Laboratory Animal Science 2012, 51: 789-96. PMID: 23294885, PMCID: PMC3508183.Peer-Reviewed Original ResearchConceptsSwiss Webster miceSoiled-bedding sentinelsInfectious agentsMouse parvovirusWebster miceMurine pathogenHealth surveillance protocolsAge-associated variabilityMode of transmissionContact sentinelsIndex miceSentinel miceMice ageHealth surveillanceMiceLocal pet storesMurine coloniesHost susceptibilityResearch colonyAgeSentinelsAgentsSusceptibilityPet storesPathogensTransmission of mouse parvovirus by fomites.
Compton SR, Paturzo FX, Smith PC, Macy JD. Transmission of mouse parvovirus by fomites. Journal Of The American Association For Laboratory Animal Science 2012, 51: 775-80. PMID: 23294883, PMCID: PMC3508181.Peer-Reviewed Original Research
1998
Interactions of Enterotropic Mouse Hepatitis Viruses with Bgp2 Receptor Proteins
Compton S. Interactions of Enterotropic Mouse Hepatitis Viruses with Bgp2 Receptor Proteins. Advances In Experimental Medicine And Biology 1998, 440: 25-31. PMID: 9782261, DOI: 10.1007/978-1-4615-5331-1_4.Peer-Reviewed Original ResearchConceptsCMT93 cellsReceptor geneEnterotropic mouse hepatitis virus infectionMouse hepatitis virus infectionHepatitis virus infectionMHV-A59 infectionLimited tissue tropismCell receptor interactionsMHV infectionNeonatal miceVirus infectionIntestinal mucosaReceptor mRNAMouse hepatitisBHK cellsReceptor isoformsUnidentified receptorInfectionMonoclonal antibodiesTissue tropismVero cellsReceptor interactionRI useReceptor proteinReceptors
1996
Growth characteristics and protein profiles of prototype and wild-type rat coronavirus isolates grown in a cloned subline of mouse fibroblasts (L2p.176 cells)
Gaertner D, Compton S, Winograd D, Smith A. Growth characteristics and protein profiles of prototype and wild-type rat coronavirus isolates grown in a cloned subline of mouse fibroblasts (L2p.176 cells). Virus Research 1996, 41: 55-68. PMID: 8725102, PMCID: PMC7134090, DOI: 10.1016/0168-1702(95)01274-5.Peer-Reviewed Original ResearchConceptsMouse hepatitis virus
1995
Molecular characterization of the S proteins of two enterotropic murine coronavirus strains
Kunita S, Zhang L, Homberger F, Compton S. Molecular characterization of the S proteins of two enterotropic murine coronavirus strains. Virus Research 1995, 35: 277-289. PMID: 7785316, PMCID: PMC7134003, DOI: 10.1016/0168-1702(94)00089-u.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, ViralBase SequenceCapsidCell LineCloning, MolecularCoronavirus M ProteinsDNA, ViralImmunoblottingMembrane GlycoproteinsMiceMolecular Sequence DataMurine hepatitis virusSequence Homology, Amino AcidSpike Glycoprotein, CoronavirusViral Core ProteinsViral Envelope ProteinsViral Matrix ProteinsVirionConceptsMHV-RIS proteinAmino acid long proteinViral proteinsMurine coronavirusProtein-specific antiserumDifferent amino acid changesAmino acid changesLong proteinInefficient cleavageMolecular characterizationAcid changesCleavage siteAmino acidsProteinS geneMHV strainsHomologyM proteinEnterotropismRespiratory strainsGenesMinor differencesMHVStrainsCharacterization of the S Protein of Enterotropic Murine Coronavirus Strain-Y
Compton S, Kunita S. Characterization of the S Protein of Enterotropic Murine Coronavirus Strain-Y. Advances In Experimental Medicine And Biology 1995, 380: 23-28. PMID: 8830485, DOI: 10.1007/978-1-4615-1899-0_3.Peer-Reviewed Original ResearchMultiple Receptor-Dependent Steps Determine the Species Specificity of HCV-229E Infection
Levis R, Cardellichio C, Scanga C, Compton S, Holmes K. Multiple Receptor-Dependent Steps Determine the Species Specificity of HCV-229E Infection. Advances In Experimental Medicine And Biology 1995, 380: 337-343. PMID: 8830504, DOI: 10.1007/978-1-4615-1899-0_55.Peer-Reviewed Original ResearchConceptsHuman aminopeptidase NSpecies specificityBrush border membraneCell linesVirus bindingHCV-229EHuman cellsAminopeptidase NCellular receptorsHCV 229E.SpeciesCell sortingIntestinal brush border membraneHuman coronavirus 229EAnimal coronavirusesBindsMembraneVirus penetrationCellsVirus yieldBorder membraneViral spikeCoronavirus 229EBindingInfection
1994
Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors
Compton S. Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors. Virology 1994, 203: 197-201. PMID: 8030279, PMCID: PMC7131022, DOI: 10.1006/viro.1994.1475.Peer-Reviewed Original ResearchConceptsSJL miceLimited tissue tropismMHV-RIEnterotropic mouse hepatitis virusBALB/c miceTissue tropismMonoclonal antibody CC1BALB/cMouse hepatitis virusRole of receptorsMurine carcinoembryonic antigenC miceEnterotropic strainsHepatitis virusCarcinoembryonic antigenBHK cellsInfectionMiceDifferent receptorsReceptorsCell linesGlycoprotein receptorsMurine tissuesMouse coronavirusMHV
1990
Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity?
Holmes K, Williams R, Cardellichio C, Compton S, Stephensen C, Snyder S, Frana M, Jiang G, Smith A, Knobler R. Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity? Advances In Experimental Medicine And Biology 1990, 276: 37-44. PMID: 1966425, DOI: 10.1007/978-1-4684-5823-7_6.Peer-Reviewed Original ResearchConceptsSJL/J miceNormal target tissuesJ miceMHV-A59BALB/c miceTarget tissuesVirus overlay protein blot assaySJL/JMouse hepatitis virusSusceptible miceBinding of virionsC miceHepatitis virusOnly receptorBlot assaysVirus bindingMiceTissue tropismIntestine membranesMurine virusesHepatocyte membraneProtein blot assayVirusInfectionMolecular mechanisms