2017
Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury – a combined in vivo and in vitro 1H–MRS study
Singh K, Trivedi R, Verma A, D'souza M, Koundal S, Rana P, Baishya B, Khushu S. Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury – a combined in vivo and in vitro 1H–MRS study. NMR In Biomedicine 2017, 30 PMID: 28759166, DOI: 10.1002/nbm.3764.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injuryDay 1Metabolic alterationsDay 5Moderate traumatic brain injuryPathological processesN-acetylaspartate levelsTrauma-induced changesSeverity of injuryProton magnetic resonance spectroscopy dataRat hippocampusGlutamine/glutamateHippocampus regionTBI groupAltered metabolitesHigher cognitive functionsCognitive functionInjuryMetabolic irregularitiesAmino acid metabolismCitric acid cycle intermediatesAltered levelsMetabolic profileOxidative stress
2015
Investigation of prolonged hypobaric hypoxia-induced change in rat brain using T2 relaxometry and diffusion tensor imaging at 7T
Koundal S, Gandhi S, Kaur T, Trivedi R, Khushu S. Investigation of prolonged hypobaric hypoxia-induced change in rat brain using T2 relaxometry and diffusion tensor imaging at 7T. Neuroscience 2015, 289: 106-113. PMID: 25592421, DOI: 10.1016/j.neuroscience.2014.12.049.Peer-Reviewed Original ResearchConceptsCorpus callosumDiffusion tensor imagingHH exposureADC valuesEdema formationT2 relaxometryGroups of ratsApparent diffusion coefficient (ADC) changesCytotoxic edema formationHypoxia-induced changesWater diffusion changesCytotoxic edemaHippocampal regionRat brainHH groupT2 valuesIron depositionTensor imagingRatsMagnetic resonance imaging modalitiesImaging modalitiesDiffusion changesHippocampusDiffusion tensorMRI modalities
2014
Neurometabolic and structural alterations in rat brain due to acute hypobaric hypoxia: in vivo 1H MRS at 7 T
Koundal S, Gandhi S, Kaur T, Khushu S. Neurometabolic and structural alterations in rat brain due to acute hypobaric hypoxia: in vivo 1H MRS at 7 T. NMR In Biomedicine 2014, 27: 341-347. PMID: 24395642, DOI: 10.1002/nbm.3068.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsBrainHippocampusHypoxiaMagnetic Resonance SpectroscopyMaleMetabolomeProtonsRatsRats, Sprague-DawleyTime FactorsConceptsAcute hypobaric hypoxiaHypobaric hypoxiaRat brainHH exposureCA2/CA3 regionDays of normoxiaMetabolite levelsProcess of demyelinationMyo-inositol levelsDays post exposureVivo 1H MRSEarly risk assessmentGlutamatergic neuronsNeurometabolic changesAstrocyte metabolismCA3 regionN-acetylaspartateHippocampus regionMetabolic alterationsPost exposureMetabolic changesNormoxiaBrainFourth dayFirst day