2024
Levels of Cytokines in Leptospirosis Patients with Different Serovars and rfb Locus
Senavirathna I, Jayasundara D, Warnasekara J, Kappagoda C, Agampodi S. Levels of Cytokines in Leptospirosis Patients with Different Serovars and rfb Locus. Journal Of Interferon & Cytokine Research 2024, 44: 80-93. PMID: 38377491, PMCID: PMC10880283, DOI: 10.1089/jir.2023.0091.Peer-Reviewed Original ResearchConceptsRfb locusGenome sequencePacBio RS II systemBacterial cell wallCulture-positive samplesLipopolysaccharide synthesisRapid AnnotationLeptospira borgpetersenii</i>,Genomic dataMicroscopic agglutination testSubsystem TechnologyLociCell wallSerovarsIsolated culturesSevere clinical manifestationsCytokine responsesLeptospira interrogans serovar autumnalisClinical manifestationsGenomeSamples of cultureSequenceRFBLevels of cytokinesSerum cytokine concentrations
2021
Clinical spectrum of endemic leptospirosis in relation to cytokine response
Dahanayaka NJ, Agampodi SB, Seneviratna I, Warnasekara J, Rajapakse R, Ranathunga K, Matthias M, Vinetz JM. Clinical spectrum of endemic leptospirosis in relation to cytokine response. PLOS ONE 2021, 16: e0261025. PMID: 34879100, PMCID: PMC8654203, DOI: 10.1371/journal.pone.0261025.Peer-Reviewed Original ResearchConceptsCytokine responsesLeptospirosis patientsClinical spectrumHigher IL-13 levelsHigher IL-5Acute kidney injuryHigher serum creatinineIL-13 levelsSerum cytokine levelsIL-6 levelsUniversity Teaching HospitalMultiplex cytokine kitKidney injuryLung involvementCytokine levelsSerum creatinineAcute phaseCytokine kitIL-1βAcute samplesConvalescence periodIL-8IL-5Prognostic informationEndemic settings
2020
Cytokine response in human leptospirosis with different clinical outcomes: a systematic review
Senavirathna I, Rathish D, Agampodi S. Cytokine response in human leptospirosis with different clinical outcomes: a systematic review. BMC Infectious Diseases 2020, 20: 268. PMID: 32264832, PMCID: PMC7137275, DOI: 10.1186/s12879-020-04986-9.Peer-Reviewed Original ResearchConceptsDifferent clinical outcomesCross-sectional studyCytokine responsesIL-10Clinical outcomesSystematic reviewDisease severityHealth Quality Assessment ToolComparative cross-sectional studyTNF-α levelsMethodsA systematic reviewMeasurement of cytokinesEnzyme-linked immunosorbent assayMicroscopic agglutination testPublic health professionalsQuality assessment toolMild leptospirosisCytokine stormElevated cytokinesObservational cohortLeptospirosis patientsProspective studyIL-1βIL-6IL-8