2024
Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights
Honhar P, Sadabad F, Tinaz S, Gallezot J, Dias M, Naganawa M, Yang Y, Henry S, Hillmer A, Gao H, Najafzadeh S, Comley R, Nabulsi N, Huang Y, Finnema S, Carson R, Matuskey D. Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights. Brain Communications 2024, 6: fcae345. PMID: 39429243, PMCID: PMC11487911, DOI: 10.1093/braincomms/fcae345.Peer-Reviewed Original ResearchDAT availabilityMotor severitySubstantia nigraDopamine transporter availabilityClinical trials of Parkinson's diseaseParkinson's diseaseLongitudinal studyTracking longitudinal changesClinical correlatesVentral striatumTransporter availabilityNigrostriatal regionParkinson's disease patientsPutamenMotor severity scoresAssociated with increasesSubstantiaDATLongitudinal changesTremor scoreNegative associationNigraSubstantia nigra of Parkinson's disease patientsTremor severityPET biomarkersAuthor Correction: Synaptic loss and its association with symptom severity in Parkinson’s disease
Holmes S, Honhar P, Tinaz S, Naganawa M, Hilmer A, Gallezot J, Dias M, Yang Y, Toyonaga T, Esterlis I, Mecca A, Van Dyck C, Henry S, Ropchan J, Nabulsi N, Louis E, Comley R, Finnema S, Carson R, Matuskey D. Author Correction: Synaptic loss and its association with symptom severity in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 55. PMID: 38472206, PMCID: PMC10933370, DOI: 10.1038/s41531-024-00674-6.Peer-Reviewed Original ResearchSynaptic loss and its association with symptom severity in Parkinson’s disease
Holmes S, Honhar P, Tinaz S, Naganawa M, Hilmer A, Gallezot J, Dias M, Yang Y, Toyonaga T, Esterlis I, Mecca A, Van Dyck C, Henry S, Ropchan J, Nabulsi N, Louis E, Comley R, Finnema S, Carson R, Matuskey D. Synaptic loss and its association with symptom severity in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 42. PMID: 38402233, PMCID: PMC10894197, DOI: 10.1038/s41531-024-00655-9.Peer-Reviewed Original ResearchSynaptic density lossPositron emission tomographyBinds to synaptic vesicle glycoprotein 2AAssociated with symptom severityParkinson's diseaseHigh-resolution positron emission tomographySynaptic vesicle glycoprotein 2ADuration of illnessPositron emission tomography scanBrain perfusionIllness durationSymptom severitySeverity of symptomsHC groupSubstantia nigraSynaptic densityLiving brainPD individualsClinical insightsDensity lossPD patientsEmission tomographyBrainSynaptic lossSynapse lossIntense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease
de Laat B, Hoye J, Stanley G, Hespeler M, Ligi J, Mohan V, Wooten D, Zhang X, Nguyen T, Key J, Colonna G, Huang Y, Nabulsi N, Patel A, Matuskey D, Morris E, Tinaz S. Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 34. PMID: 38336768, PMCID: PMC10858031, DOI: 10.1038/s41531-024-00641-1.Peer-Reviewed Original ResearchDopamine transporterSubstantia nigraDopaminergic neuronsDopamine transporter availabilityNeuroprotective effects of exerciseDopaminergic systemClinical progression of PDEarly PDSubstantiaNeuromelanin contentNigraLoss of dopaminergic neuronsEffects of exerciseNM-MRIDopamineSystem of patientsProgressive loss of dopaminergic neuronsParkinson's diseaseClinical progressionProgression of PDNeuroprotective effectsClinical trialsIntensity exercisePET imagingProgressive loss
2023
Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study
McGurrin P, Norato G, Thompson‐Westra J, McCrossin G, Lines E, Lungu C, Pandey S, Tinaz S, Voller B, Ramchandani V, Hallett M, Haubenberger D. Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study. Annals Of Clinical And Translational Neurology 2023, 11: 156-168. PMID: 38087917, PMCID: PMC10791018, DOI: 10.1002/acn3.51943.Peer-Reviewed Original ResearchObjective responseEthanol administrationEssential tremorSingle-dose challengeThird of patientsPrior ethanol exposureTremor frequencyBreath alcohol levelsMechanism of actionResponder rateEthanol doseBreath alcohol concentrationAcute ethanolEthanol exposureResponder statusAlcohol concentration levelsET patientsChallenge studiesPatientsTremor reductionAlcohol levelsOral ethanolResponse definitionsSecondary analysisTremor severityMeasuring Heart Rate Accurately in Patients With Parkinson Disease During Intense Exercise: Usability Study of Fitbit Charge 4
Colonna G, Hoye J, de Laat B, Stanley G, Ibrahimy A, Tinaz S, Morris E. Measuring Heart Rate Accurately in Patients With Parkinson Disease During Intense Exercise: Usability Study of Fitbit Charge 4. JMIR Biomedical Engineering 2023, 8: e51515. PMID: 38875680, PMCID: PMC11041416, DOI: 10.2196/51515.Peer-Reviewed Original ResearchTheoretical maximum heart rateHeart rateParkinson's diseaseExercise sessionsIntense exerciseExercise programExercise intensityHigh-intensity exercise sessionsEarly-stage Parkinson's diseaseIntensive exercise programAerobic physical exerciseCohort of patientsBackground Parkinson’s diseaseRole of exerciseHigh-intensity exerciseCommon neurodegenerative diseaseMean heart rateMaximum heart rateHR monitorAverage heart rateR interval measurementRecent pilot studyPolar H10Nonmotor symptomsClinical cohortMagnetic resonance imaging modalities aid in the differential diagnosis of atypical parkinsonian syndromes
Tinaz S. Magnetic resonance imaging modalities aid in the differential diagnosis of atypical parkinsonian syndromes. Frontiers In Neurology 2023, 14: 1082060. PMID: 36816565, PMCID: PMC9932598, DOI: 10.3389/fneur.2023.1082060.Peer-Reviewed Original ResearchAtypical parkinsonian syndromesParkinsonian syndromesParkinson's diseaseIdiopathic Parkinson's diseaseDisease courseClinical manifestationsDifferential diagnosisTimely diagnosisModalities aidDiagnostic criteriaClinical practiceMRI toolsMagnetic resonance imaging (MRI) technologyNuclear imagingDiagnosisDiagnostic useSyndromeMRI modalitiesDiseaseDiagnostic purposesModalitiesStroke in Parkinson’s disease: a review of epidemiological studies and potential pathophysiological mechanisms
Elfil M, Bayoumi A, Sayed A, Aladawi M, Aboutaleb P, Grieb L, Tolba H, Tinaz S. Stroke in Parkinson’s disease: a review of epidemiological studies and potential pathophysiological mechanisms. Acta Neurologica Belgica 2023, 123: 773-783. PMID: 36710306, DOI: 10.1007/s13760-023-02202-4.Peer-Reviewed Original ResearchConceptsParkinson's diseaseEpidemiological studiesNeurological disordersRate of PDCumulative cardiovascular riskRisk of strokePost-stroke complicationsPotential pathophysiological mechanismsRecent epidemiological studiesQuality of lifeCardiovascular riskIschemic insultPathophysiological mechanismsPD patientsNeurological causesEtiological factorsSleep disordersMotor impairmentStrokeDiseasePathological processesDisordersRiskReviewMorbidity
2022
Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease
Cherry J, Kamel S, Elfil M, Aravala S, Bayoumi A, Patel A, Sinha R, Tinaz S. Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease. Brain Imaging And Behavior 2022, 17: 161-171. PMID: 36434490, PMCID: PMC10050121, DOI: 10.1007/s11682-022-00749-z.Peer-Reviewed Original ResearchConceptsImagery trainingFunctional connectivity changesMild Parkinson's diseaseVisual imagery trainingMental imagery trainingComplex cognitive processesConnectivity changesMotor imagery trainingBrain functional connectivity changesFunctional connectivity characteristicsExecutive processesMental imageryCognitive processesPerceptual experienceNeural correlatesBrain mechanismsImagery practiceImagery contentSensorimotor processesNeuropsychiatric patient populationsMotor functionMotor actsMotor enhancementBrain areasParkinson's diseaseCharacterization of Early Stage Parkinson's Disease From Resting-State fMRI Data Using a Long Short-Term Memory Network
Guo X, Tinaz S, Dvornek N. Characterization of Early Stage Parkinson's Disease From Resting-State fMRI Data Using a Long Short-Term Memory Network. Frontiers In Neuroimaging 2022, 1: 952084. PMID: 37555151, PMCID: PMC10406199, DOI: 10.3389/fnimg.2022.952084.Peer-Reviewed Original ResearchEarly-stage Parkinson's diseaseFunctional magnetic resonance imagingParkinson's Progression Markers InitiativeParkinson's diseaseProgression Markers InitiativeDiagnosis of PDEarly-stage diseaseFunctional brain changesBrain function alterationsStage Parkinson's diseaseFunctional connectivity differencesComplex neurodegenerative disorderMagnetic resonance imagingResting-state fMRI dataStage diseaseDisease stageDisease progressionBrain changesTreatment responseMotor impairmentFC changesNew therapiesFunction alterationsResonance imagingBrain regions
2019
Parkinson's Disease Dementia and Lewy Body Disease
Sezgin M, Bilgic B, Tinaz S, Emre M. Parkinson's Disease Dementia and Lewy Body Disease. Seminars In Neurology 2019, 39: 274-282. PMID: 30925619, DOI: 10.1055/s-0039-1678579.Peer-Reviewed Original ResearchConceptsParkinson's disease dementiaDisease dementiaCognitive symptomsBehavioral symptomsLewy body diseaseCerebrospinal fluid biomarkersTime of onsetAutonomic dysfunctionExtrapyramidal symptomsBody diseaseClinical featuresNeuropathological findingsNeuropsychiatric symptomsRandomized trialsClinical pictureLewy bodiesFluid biomarkersClinical differentiationSleep disordersCholinesterase inhibitorsCognitive impairmentSymptomsDementiaNeurodegenerative disordersDLB
2018
Insula as the Interface Between Body Awareness and Movement: A Neurofeedback-Guided Kinesthetic Motor Imagery Study in Parkinson’s Disease
Tinaz S, Para K, Vives-Rodriguez A, Martinez-Kaigi V, Nalamada K, Sezgin M, Scheinost D, Hampson M, Louis ED, Constable RT. Insula as the Interface Between Body Awareness and Movement: A Neurofeedback-Guided Kinesthetic Motor Imagery Study in Parkinson’s Disease. Frontiers In Human Neuroscience 2018, 12: 496. PMID: 30581383, PMCID: PMC6292989, DOI: 10.3389/fnhum.2018.00496.Peer-Reviewed Original ResearchCortical-basal ganglia circuitsDorsomedial frontal cortexFunctional connectivityMotor imageryMotivational contextIntentional movementMotor imagery strategyFunctional magnetic resonanceFrontal cortexNeural circuit modelKinesthetic motor imageryParkinson's diseaseLimbic circuitsMotor imagery studiesGanglia circuitsImagery strategyInternal motivationSensory cuesImagery studiesNeurofeedback sessionsSustain movementSensory signalsMotor preparednessCortex circuitBody awarenessA comparison of resting-state functional magnetic resonance imaging between Neurological and Liver-only affected Wilson’s Disease patients (P4.014)
Nalamada K, Tinaz S, Arora J, Vives-Rodriguez A, Constable T, Schilsky M, Robakis D. A comparison of resting-state functional magnetic resonance imaging between Neurological and Liver-only affected Wilson’s Disease patients (P4.014). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p4.014.Peer-Reviewed Original ResearchFunctional Magnetic Resonance Imaging-Based Neurofeedback Training in Patients with Parkinson’s Disease (P3.075)
Tinaz S, Nalamada K, Sezgin M, Vives-Rodriguez A, Para K, Scheinost D, Louis E, Hampson M. Functional Magnetic Resonance Imaging-Based Neurofeedback Training in Patients with Parkinson’s Disease (P3.075). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p3.075.Peer-Reviewed Original ResearchSemiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease
Tinaz S, Chow C, Kuo PH, Krupinski EA, Blumenfeld H, Louis ED, Zubal G. Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease. Clinical Nuclear Medicine 2018, 43: e1-e7. PMID: 29112012, PMCID: PMC7257254, DOI: 10.1097/rlu.0000000000001885.Peer-Reviewed Original ResearchConceptsStriatal binding ratiosDAT scanParkinson's diseaseParkinson's Progression Markers Initiative (PPMI) databaseDopamine transporter imagingDopamine transporter scanAdjunct diagnostic toolBinding ratioOutpatient cohortPPMI cohortTransporter imagingParkinsonian disordersMotor severityHealthy controlsClinical measuresStriatal regionsVisual readsTest cohortTest patientsSignificant negative correlationPatientsPPMI databaseDiagnostic aidCohortTraining group
2016
Changes in functional organization and white matter integrity in the connectome in Parkinson's disease
Tinaz S, Lauro PM, Ghosh P, Lungu C, Horovitz SG. Changes in functional organization and white matter integrity in the connectome in Parkinson's disease. NeuroImage Clinical 2016, 13: 395-404. PMID: 28116232, PMCID: PMC5226806, DOI: 10.1016/j.nicl.2016.12.019.Peer-Reviewed Original ResearchConceptsParkinson's diseaseWhite matter integrityPD patientsPD groupWhite matter connectivity changesResting-state functional MRINon-demented PD patientsEarly disease stagesCortico-striatal circuitsWhite matter connectivityDopaminergic medicationDorsal attention networkDisease stageFunctional organizationSensorimotor networkWhole-brain connectomeFunctional modular organizationWhite matterFunctional MRIConnectivity changesDiseasePatientsDiffusion tensorDefault modeBrain connectomeThe Basal Ganglia and Decision-Making in Neuropsychiatric Disorders
Tinaz S, Stern C. The Basal Ganglia and Decision-Making in Neuropsychiatric Disorders. Innovations In Cognitive Neuroscience 2016, 339-361. DOI: 10.1007/978-3-319-42743-0_15.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderDecision-making deficitsGoal-directed actionsDecision-making researchDeficit hyperactivity disorderPotential neurophysiological mechanismsFunctional neuroimaging methodsObsessive-compulsive disorderNeuropsychiatric disordersNeural correlatesHyperactivity disorderBasic rewardsCompulsive disorderNeurophysiological mechanismsNeuroimaging methodsBasal ganglia-cortical circuitsOverview of termsNeuropsychiatric conditionsComputational modelDetailed computational modelDecision makingMood disordersDifferent neuropsychiatric disordersRewardDecision-making processSequence Effect in Parkinson’s Disease Is Related to Motor Energetic Cost
Tinaz S, Pillai AS, Hallett M. Sequence Effect in Parkinson’s Disease Is Related to Motor Energetic Cost. Frontiers In Neurology 2016, 7: 83. PMID: 27252678, PMCID: PMC4877367, DOI: 10.3389/fneur.2016.00083.Peer-Reviewed Original ResearchParkinson's diseaseDopaminergic treatmentIsometric motor tasksVisual feedbackMotor symptomsPD patientsExternal cueingMedication statusPatientsMotor outputRepetitive movementsMajor causeMotor tasksDiseaseHighest motor costMotor plansBradykinesiaMotor controlMotor vigorMotivational cuesRapid decrementTreatmentMorbidityMixed resultsControlDeficits in Sensorimotor Networks in Functional Movement Disorders: A Graph-Theory Based Network Analysis (P1.070)
Maurer C, LaFaver K, Tinaz S, Hallett M, Horovitz S. Deficits in Sensorimotor Networks in Functional Movement Disorders: A Graph-Theory Based Network Analysis (P1.070). Neurology 2016, 86 DOI: 10.1212/wnl.86.16_supplement.p1.070.Peer-Reviewed Original Research
2015
Role of the right dorsal anterior insula in the urge to tic in tourette syndrome
Tinaz S, Malone P, Hallett M, Horovitz SG. Role of the right dorsal anterior insula in the urge to tic in tourette syndrome. Movement Disorders 2015, 30: 1190-1197. PMID: 25855089, PMCID: PMC5088605, DOI: 10.1002/mds.26230.Peer-Reviewed Original ResearchConceptsRight dorsal anterior insulaDorsal anterior insulaTourette syndromeAnterior insulaFunctional connectivityBilateral supplementary motor areaResting-state functional magnetic resonance imagingAdult Tourette patientsSupplementary motor areaDorsal-anterior partFunctional magnetic resonance imagingMagnetic resonance imagingCortico-striatoTourette patientsUrge suppressionHealthy subjectsMotor areaThalamic regionsTic severityPremonitory urgesPatientsSyndromeUrge severityResonance imagingTic generation