2023
Downregulation of a tumor suppressor gene LKB1 in lung transplantation as a biomarker for chronic murine lung allograft rejection
Rahman M, Ravichandran R, Sankpal N, Bansal S, Sureshbabu A, Fleming T, Perincheri S, Bharat A, Smith M, Bremner R, Mohanakumar T. Downregulation of a tumor suppressor gene LKB1 in lung transplantation as a biomarker for chronic murine lung allograft rejection. Cellular Immunology 2023, 386: 104690. PMID: 36812767, PMCID: PMC11019891, DOI: 10.1016/j.cellimm.2023.104690.Peer-Reviewed Original ResearchConceptsLung allograft rejectionLung transplantationAllograft rejectionChronic lung allograft rejectionBronchiolitis obliterans syndromeLung transplant recipientsTumor suppressor gene LKB1Phosphorylated mammalian targetBEAS-2B cellsObliterans syndromeChronic rejectionTransplant recipientsDonor lungsSingle lungB6D2F1 miceMurine modelDBA/2J miceMTOR expressionMammalian targetLKB1 overexpressionSignificant downregulationLungLKB1 knockdownA549 cellsLKB1 activity
2022
Lung Transplant Recipients with SARS-CoV-2 Infection Induce Circulating Exosomes with SARS-CoV-2 Spike Protein S2 Which Are Immunogenic in Mice
Bansal S, Fleming T, Perincheri S, Smith M, Bremner R, Mohanakumar T. Lung Transplant Recipients with SARS-CoV-2 Infection Induce Circulating Exosomes with SARS-CoV-2 Spike Protein S2 Which Are Immunogenic in Mice. The Journal Of Heart And Lung Transplantation 2022, 41: s134. PMCID: PMC8988572, DOI: 10.1016/j.healun.2022.01.314.Peer-Reviewed Original ResearchSARS-CoV-2 spike proteinSARS-CoV-2SARS-CoV-2 infectionSARS-CoV-2 spike antigenLung transplant recipientsSpike proteinTransplant recipientsSpike antigenNucleocapsid antigenSARS-CoV-2 infection inducesSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Conclusion SARS-CoV-2Lungs of miceSyndrome coronavirus 2Important risk factorSARS-CoV-2 spikeSpike protein antigensC57BL/6 miceCoronavirus 2Severe inflammationInfection inducesRisk factorsViral antigens
2021
Chronic Lung Allograft Dysfunction: Role for Tumor Suppressor Gene Liver Kinase B1
Rahman M, Ravichandran R, Bansal S, Liu W, Perincheri S, Angara S, Fleming T, Bharat A, Hachem R, Smith M, Bremner R, Mohanakumar T. Chronic Lung Allograft Dysfunction: Role for Tumor Suppressor Gene Liver Kinase B1. The Journal Of Heart And Lung Transplantation 2021, 40: s60. DOI: 10.1016/j.healun.2021.01.1886.Peer-Reviewed Original ResearchChronic lung allograft dysfunctionBronchiolitis obliterans syndromeLung transplant modelLung transplant recipientsLiver kinase B1Epithelial-mesenchymal transformationΑ-SMAChronic rejectionTransplant recipientsBEAS-2BTransplant modelHypoxia/reperfusion (H/R) modelKnockdown of LKB1Lung allograft dysfunctionQRT-PCRAirway epithelial cell lineMiR-155 levelsExosome releaseHypoxia/reperfusionRole of LKB1Upregulation of vimentinAllograft dysfunctionLung transplantationObliterans syndromeCLAD development