The HDAC Inhibitor TSA Inhibits Cell Proliferation, Induces Apoptosis and Down-Regulates HER2 Protein and Gene Expression as a Single Agent and in Combination with Trastuzumab in Trastuzumab-Sensitive and -Resistant Breast Cancer Cell Lines.
Radke S, Perincheri S, Schulz V, Lerner B, Kumar A, Chandrasekan L, Tuck D, Harris L. The HDAC Inhibitor TSA Inhibits Cell Proliferation, Induces Apoptosis and Down-Regulates HER2 Protein and Gene Expression as a Single Agent and in Combination with Trastuzumab in Trastuzumab-Sensitive and -Resistant Breast Cancer Cell Lines. Cancer Research 2009, 69: 3133-3133. DOI: 10.1158/0008-5472.sabcs-09-3133.Peer-Reviewed Original ResearchRole of HDACiHistone deacetylase inhibitorsTrastuzumab-resistant breast cancerBreast cancerBreast cancer cell linesHER2 proteinCancer cell linesSingle agentResistant breast cancer cell linesCell linesHER2-positive breast cancerFirst biological therapyHER2 antibody trastuzumabValue of HER2Positive breast cancerTSA treatmentNormal breast epitheliumNormal breast cell lineAlternative therapeutic strategiesBreast cancer cellsGrowth inhibitory effectsInhibited cell survivalHDAC inhibitor trichostatinResistant cell linesMechanism of action