2015
The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization
Ullah G, Wei Y, Dahlem M, Wechselberger M, Schiff S. The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization. PLOS Computational Biology 2015, 11: e1004414. PMID: 26273829, PMCID: PMC4537206, DOI: 10.1371/journal.pcbi.1004414.Peer-Reviewed Original ResearchMeSH KeywordsBrainCell SizeCellular MicroenvironmentComputational BiologyDepressionHumansHypoxiaModels, NeurologicalNeuronsSeizuresConceptsAnoxic depolarizationCell swellingDynamics of seizuresGlial KNeuroprotective roleSpreading DepressionEpileptic seizuresSeizuresPhysiological ceilingDepression statePathological activityCell volumeNeuronal dynamicsDepressionPathological statesSeparate seizuresIntervention strategiesNeuron membraneDepolarizationUse of volumeNeuronal behaviorOxygen homeostasisOxygen supplyCells swellSwelling
2012
Reconstructing Mammalian Sleep Dynamics with Data Assimilation
Sedigh-Sarvestani M, Schiff S, Gluckman B. Reconstructing Mammalian Sleep Dynamics with Data Assimilation. PLOS Computational Biology 2012, 8: e1002788. PMID: 23209396, PMCID: PMC3510073, DOI: 10.1371/journal.pcbi.1002788.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsComputational BiologyComputer SimulationModels, BiologicalRatsSleepWakefulnessConceptsUnscented Kalman filterData assimilationData assimilation frameworkParameter estimation methodNonlinear computational modelSleep-wake regulatory networkAssimilation frameworkUnknown parametersHidden variablesCovariance inflationNoisy variablesSlow dynamicsSparse measurementsComputational modelModel parametersKalman filterModel statesEstimation methodSimulation studyComplex systemsOptimal variablesFilter modelUKF frameworkModel variablesPartial observability