2017
Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda
Kulkarni A, Schiff S, Mbabazi-Kabachelor E, Mugamba J, Ssenyonga P, Donnelly R, Levenbach J, Monga V, Peterson M, MacDonald M, Cherukuri V, Warf B. Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda. New England Journal Of Medicine 2017, 377: 2456-2464. PMID: 29262276, PMCID: PMC5784827, DOI: 10.1056/nejmoa1707568.Peer-Reviewed Original ResearchConceptsETV-CPCPostinfectious hydrocephalusUgandan infantsTreatment failureCognitive outcomesBrain volumeSingle-center studyEndoscopic third ventriculostomyChoroid plexus cauterizationMajor health problemSignificant differencesLanguage scoresSecondary outcomesEndoscopic treatmentPrimary outcomeVentricular sizeThird ventriculostomyInfant hydrocephalusComputed tomographyTreatment groupsAlternative treatmentLate failureBayley ScalesBrain growthConventional treatment
2000
Long-Term Follow-Up Data from the Shunt Design Trial
Kestle J, Drake J, Milner R, Sainte-Rose C, Cinalli G, Boop F, Piatt J, Haines S, Schiff S, Cochrane D, Steinbok P, MacNeil N. Long-Term Follow-Up Data from the Shunt Design Trial. Pediatric Neurosurgery 2000, 33: 230-236. PMID: 11155058, DOI: 10.1159/000055960.Peer-Reviewed Original ResearchConceptsFirst shunt failureShunt failureDifferential pressure valvesOverall shunt survivalShunt Design TrialShunt failure ratesLate complicationsShunt surgeryShunt survivalInitial treatmentTerm followShunt obstructionDelta valvesHydrocephalic childrenOriginal trialPediatric hydrocephalusSurvival advantagePatient statusPatientsTrialsDesign trialSignificant differencesObstructionOverdrainageInfection