2021
Spreading depression as an innate antiseizure mechanism
Tamim I, Chung D, de Morais A, Loonen I, Qin T, Misra A, Schlunk F, Endres M, Schiff S, Ayata C. Spreading depression as an innate antiseizure mechanism. Nature Communications 2021, 12: 2206. PMID: 33850125, PMCID: PMC8044138, DOI: 10.1038/s41467-021-22464-x.Peer-Reviewed Original ResearchConceptsFocal neocortical seizuresSystemic kainic acidCentral nervous systemVivo mouse modelAntiseizure mechanismsAntiseizure effectsSeizure generalizationFocal seizuresSD occurrenceNeocortical seizuresKainic acidBrain injuryMouse modelNervous systemSeizuresNeurological disordersProlonged depolarizationSDDepressionBicucullineMigraineInjury
2018
A Brain–Heart Biomarker for Epileptogenesis
Bahari F, Ssentongo P, Schiff S, Gluckman B. A Brain–Heart Biomarker for Epileptogenesis. Journal Of Neuroscience 2018, 38: 8473-8483. PMID: 30150365, PMCID: PMC6158692, DOI: 10.1523/jneurosci.1130-18.2018.Peer-Reviewed Original ResearchConceptsBrain-heart interactionsBiomarkers of epileptogenesisDevelopment of epilepsyAutonomic cardiac activityIdentification of patientsPostinjury epilepsyPreventable sequelaeFirst seizureBrain insultsCortical dischargesMale miceEpileptogenesisMurine modelMouse modelCardiac rhythmReliable biomarkersEpilepsyChronic measurementTreatment developmentBiomarkersSuch treatmentCardiac activityTherapeutic purposesBrain activityPatients