2019
The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial.
Punchak M, Mbabazi Kabachelor E, Ogwal M, Nalule E, Nalwoga J, Ssenyonga P, Mugamba J, Rattani A, Dewan M, Kulkarni A, Schiff S, Warf B. The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial. Neurosurgery 2019, 85: e714-e721. PMID: 31086941, PMCID: PMC7534394, DOI: 10.1093/neuros/nyz122.Peer-Reviewed Original ResearchConceptsChoroid plexus cauterizationETV/CPCPostoperative seizure incidencePostinfectious hydrocephalusSeizure incidenceEndoscopic third ventriculostomyUgandan infantsShunt placementMantel-Haenszel hazard ratiosKaplan-Meier methodVentriculoperitoneal shunt placementPostoperative epilepsyPostoperative seizuresPreoperative symptomsEpilepsy incidenceFirst seizureHazard ratioControlled TrialsEndoscopic treatmentThird ventriculostomyTreatment modalitiesSeizure riskHead circumferenceRelative riskSeizure onset
2018
A Brain–Heart Biomarker for Epileptogenesis
Bahari F, Ssentongo P, Schiff S, Gluckman B. A Brain–Heart Biomarker for Epileptogenesis. Journal Of Neuroscience 2018, 38: 8473-8483. PMID: 30150365, PMCID: PMC6158692, DOI: 10.1523/jneurosci.1130-18.2018.Peer-Reviewed Original ResearchConceptsBrain-heart interactionsBiomarkers of epileptogenesisDevelopment of epilepsyAutonomic cardiac activityIdentification of patientsPostinjury epilepsyPreventable sequelaeFirst seizureBrain insultsCortical dischargesMale miceEpileptogenesisMurine modelMouse modelCardiac rhythmReliable biomarkersEpilepsyChronic measurementTreatment developmentBiomarkersSuch treatmentCardiac activityTherapeutic purposesBrain activityPatients