2019
The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial.
Punchak M, Mbabazi Kabachelor E, Ogwal M, Nalule E, Nalwoga J, Ssenyonga P, Mugamba J, Rattani A, Dewan M, Kulkarni A, Schiff S, Warf B. The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial. Neurosurgery 2019, 85: e714-e721. PMID: 31086941, PMCID: PMC7534394, DOI: 10.1093/neuros/nyz122.Peer-Reviewed Original ResearchConceptsChoroid plexus cauterizationETV/CPCPostoperative seizure incidencePostinfectious hydrocephalusSeizure incidenceEndoscopic third ventriculostomyUgandan infantsShunt placementMantel-Haenszel hazard ratiosKaplan-Meier methodVentriculoperitoneal shunt placementPostoperative epilepsyPostoperative seizuresPreoperative symptomsEpilepsy incidenceFirst seizureHazard ratioControlled TrialsEndoscopic treatmentThird ventriculostomyTreatment modalitiesSeizure riskHead circumferenceRelative riskSeizure onset
2017
Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda
Kulkarni A, Schiff S, Mbabazi-Kabachelor E, Mugamba J, Ssenyonga P, Donnelly R, Levenbach J, Monga V, Peterson M, MacDonald M, Cherukuri V, Warf B. Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda. New England Journal Of Medicine 2017, 377: 2456-2464. PMID: 29262276, PMCID: PMC5784827, DOI: 10.1056/nejmoa1707568.Peer-Reviewed Original ResearchConceptsETV-CPCPostinfectious hydrocephalusUgandan infantsTreatment failureCognitive outcomesBrain volumeSingle-center studyEndoscopic third ventriculostomyChoroid plexus cauterizationMajor health problemSignificant differencesLanguage scoresSecondary outcomesEndoscopic treatmentPrimary outcomeVentricular sizeThird ventriculostomyInfant hydrocephalusComputed tomographyTreatment groupsAlternative treatmentLate failureBayley ScalesBrain growthConventional treatment