2018
Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone
Young LH, Viscoli CM, Schwartz GG, Inzucchi SE, Curtis JP, Gorman MJ, Furie KL, Conwit R, Spatz E, Lovejoy A, Abbott JD, Jacoby DL, Kolansky DM, Ling FS, Pfau SE, Kernan WN. Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone. Circulation 2018, 138: 1210-1220. PMID: 29934374, PMCID: PMC6202153, DOI: 10.1161/circulationaha.118.034763.Peer-Reviewed Original ResearchConceptsRisk of HFTransient ischemic attackEffect of pioglitazoneHF riskHeart failureInsulin-resistant patientsMyocardial infarctionIschemic attackCardiovascular benefitsIschemic strokeDiabetes mellitusInsulin resistanceHigher C-reactive proteinComposite of strokeHF risk scoreHigher HF riskDrug dose reductionHospitalized heart failureIncident myocardial infarctionLower mean doseC-reactive proteinBaseline patient featuresHF hospitalizationCardiovascular eventsPlacebo groupMultimodality Imaging Involving Magnetic Resonance Facilitates Giant Symptomatic Myxoma Resection
Hur DJ, Prescher LM, Meadows JL, Pfau SE, Homer RJ, Tellides G, Yun JJ. Multimodality Imaging Involving Magnetic Resonance Facilitates Giant Symptomatic Myxoma Resection. The Annals Of Thoracic Surgery 2018, 107: e15-e17. PMID: 30558736, DOI: 10.1016/j.athoracsur.2018.05.083.Peer-Reviewed Case Reports and Technical Notes
2017
Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack
Young LH, Viscoli CM, Curtis JP, Inzucchi SE, Schwartz GG, Lovejoy AM, Furie KL, Gorman MJ, Conwit R, Abbott JD, Jacoby DL, Kolansky DM, Pfau SE, Ling FS, Kernan WN. Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack. Circulation 2017, 135: 1882-1893. PMID: 28246237, PMCID: PMC5511545, DOI: 10.1161/circulationaha.116.024863.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeType 1 myocardial infarctionTransient ischemic attackMyocardial infarctionCoronary syndromeInsulin resistanceIschemic attackIschemic strokeDiabetes mellitusSerum troponinAcute coronary syndrome episodeMean age 63 yearsAcute coronary syndrome eventIndependent clinical events committeeType 2 myocardial infarctionIRIS participantsImpact of pioglitazoneRecent cerebrovascular eventsRecent ischemic strokeClinical events committeeAge 63 yearsEffect of pioglitazoneSmall myocardial infarctionCoronary artery diseaseST-segment elevation
2009
Interleukin-17 and Interferon-γ Are Produced Concomitantly by Human Coronary Artery–Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells
Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G. Interleukin-17 and Interferon-γ Are Produced Concomitantly by Human Coronary Artery–Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells. Circulation 2009, 119: 1424-1432. PMID: 19255340, PMCID: PMC2898514, DOI: 10.1161/circulationaha.108.827618.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCD4-Positive T-LymphocytesCells, CulturedChemokine CXCL10Coronary Artery DiseaseCoronary VesselsFemaleGene Expression RegulationHumansInflammation MediatorsInterferon-gammaInterleukin-17Interleukin-6Interleukin-8InterleukinsMaleMiddle AgedMuscle, Smooth, VascularMyocytes, Smooth MuscleReceptors, InterferonReceptors, Interleukin-17Signal TransductionT-Lymphocyte SubsetsTransforming Growth Factor beta1VasculitisConceptsVascular smooth muscle cellsSmooth muscle cellsIL-17IFN-gammaT cellsCoronary atherosclerosisMuscle cellsCoronary arteryIL-6Signature cytokinesIL-17 plasma levelsCultured vascular smooth muscle cellsIL-17 synthesisIL-17 responsesHuman coronary atherosclerosisIL-17 secretionSubset of patientsIL-17 producersT helper cellsIFN-gamma synthesisIFN-gamma producersYoung healthy individualsAtherosclerotic coronary arteriesHuman coronary arteriesTh17 cells
2007
An Inflammatory Pathway of IFN-γ Production in Coronary Atherosclerosis
Ranjbaran H, Sokol SI, Gallo A, Eid RE, Iakimov AO, D’Alessio A, Kapoor JR, Akhtar S, Howes CJ, Aslan M, Pfau S, Pober JS, Tellides G. An Inflammatory Pathway of IFN-γ Production in Coronary Atherosclerosis. The Journal Of Immunology 2007, 178: 592-604. PMID: 17182600, DOI: 10.4049/jimmunol.178.1.592.Peer-Reviewed Original ResearchConceptsIL-12/ILIFN-gamma-inducible chemokinesCoronary atherosclerosisIL-12IL-18IFN-gammaPlasma levelsT cellsTh1-type cytokine productionHuman atherosclerotic coronary arteriesAcute coronary syndromeSubset of patientsHuman coronary atherosclerosisTh1-type cytokinesC-reactive proteinIFN-γ productionElevated plasma levelsPlasma of patientsInnate immune responseAtherosclerotic coronary arteriesCoronary syndromeSystemic inflammationCardiac catheterizationCardiopulmonary bypassGamma secretion
2003
Brachytherapy for in-stent restenosis in general interventional practice A single institution's experience using four radiation devices
Singh HS, Roberts KB, Yue N, Nath R, Song GH, Azimi N, Pfau S. Brachytherapy for in-stent restenosis in general interventional practice A single institution's experience using four radiation devices. Cardiovascular Revascularization Medicine 2003, 4: 126-132. PMID: 14984712, DOI: 10.1016/s1522-1865(03)00183-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryBlood Vessel Prosthesis ImplantationBrachytherapyConnecticutCoronary AngiographyCoronary Artery BypassCoronary RestenosisCoronary StenosisEquipment DesignFamily PracticeFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedRadiation DosageReoperationRetrospective StudiesStentsTreatment OutcomeConceptsMajor adverse cardiac eventsStent restenosisAverage treatment ageEffectiveness of brachytherapyAdverse cardiac eventsSingle institution experienceMinimal lumen diameterRandomized clinical trialsLesion-specific characteristicsSpectrum of patientsMACE rateHospital deathCardiac eventsRenal failureUnstable anginaClinical outcomesCoronary lesionsTreatment failureInstitution experienceFrequent presentationInterventional therapyClinical trialsGeneral populationInterventional practicePatientsElectromechanical mapping for detecting myocardial viability and ischemia in patients with severe ischemic cardiomyopathy
Samady H, Liu Y, Choi CJ, Ragosta M, Pfau SE, Cleman MW, Powers ER, Kramer CM, Wackers F, Beller GA, Watson DD. Electromechanical mapping for detecting myocardial viability and ischemia in patients with severe ischemic cardiomyopathy. The American Journal Of Cardiology 2003, 91: 807-811. PMID: 12667565, DOI: 10.1016/s0002-9149(03)00013-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedBody Surface Potential MappingCardiomyopathiesCell SurvivalElectrophysiologic Techniques, CardiacFemaleHumansMaleMiddle AgedMyocardial IschemiaMyocardiumPredictive Value of TestsRadiopharmaceuticalsRestROC CurveSensitivity and SpecificitySeverity of Illness IndexStatistics as TopicStress, PhysiologicalStroke VolumeTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsSevere ischemic cardiomyopathyIschemic cardiomyopathyViable myocardiumMyocardial viabilityDipyridamole single-photon emissionUnipolar voltageDysfunctional myocardial segmentsBipolar voltageSingle photon emissionDipyridamole SPECTDipyridamole technetiumQuantitative technetiumInducible ischemiaNonviable segmentsNonviable myocardiumElectromechanical mappingMyocardial segmentsTracer uptakePatientsViable segmentsLogistic regressionCardiomyopathyMyocardiumIschemiaSPECT
2001
Effect of Non–Insulin-Dependent Diabetes Mellitus on Myocardial Insulin Responsiveness in Patients With Ischemic Heart Disease
Jagasia D, Whiting J, Concato J, Pfau S, McNulty P. Effect of Non–Insulin-Dependent Diabetes Mellitus on Myocardial Insulin Responsiveness in Patients With Ischemic Heart Disease. Circulation 2001, 103: 1734-1739. PMID: 11282903, DOI: 10.1161/01.cir.103.13.1734.Peer-Reviewed Original ResearchConceptsGlucose uptakeMyocardial insulin responsivenessCoronary disease patientsCoronary blood flowDependent diabetes mellitusIschemic heart diseaseMyocardium of patientsPoor clinical outcomeNet lactate uptakeCardiac glucose uptakeFractional extractionClinical outcomesDiabetes mellitusNon-InsulinInsulin levelsInsulin resistanceCardiac responsivenessDisease patientsInsulin infusionHeart diseaseMyocardial ischemiaPeripheral tissuesGlucose levelsBlood flowArterial plasmaSerum complement activation in congestive heart failure
Clark D, Cleman M, Pfau S, Rollins S, Ramahi T, Mayer C, Caulin-Glaser T, Daher E, Kosiborod M, Bell L, Setaro J. Serum complement activation in congestive heart failure. American Heart Journal 2001, 141: 684-690. PMID: 11275938, DOI: 10.1067/mhj.2001.113758.Peer-Reviewed Original ResearchConceptsCongestive heart failureSymptomatic heart failureC5b-9 levelsHeart failureClinical outcomesC5b-9Control patientsNew York Heart Association class IV symptomsComplement activationAge-matched control patientsClass IV symptomsCombined clinical outcomeAdverse clinical outcomesVentricular ejection fractionTerminal complement complex C5b-9Terminal complement activationComplement complex C5b-9Serum complement activationTerminal complement complexAdverse eventsCardiopulmonary bypassEjection fractionSerum levelsMyocardial injuryMyocardial infarction
2000
Effect of plasma insulin level on myocardial blood flow and its mechanism of action
McNulty P, Pfau S, Deckelbaum L. Effect of plasma insulin level on myocardial blood flow and its mechanism of action. The American Journal Of Cardiology 2000, 85: 161-165. PMID: 10955370, DOI: 10.1016/s0002-9149(99)00650-5.Peer-Reviewed Original ResearchConceptsMyocardial blood flowBlood flowInsulin levelsInsulin concentrationsCoronary sinus blood flowSystemic insulin levelsVenous plasma insulinSinus blood flowMyocardial oxygen demandCoronary blood flowCoronary heart diseasePlasma insulin levelsPlasma insulin concentrationMyocardial oxygen consumptionOxidative substrate metabolismMechanism of actionCoronary toneVasoactive substancesIntracoronary infusionCoronary endotheliumCoronary circulationPlasma insulinInsulin infusionHeart diseasePhysiologic elevations
1998
Modulation of Circulating Cellular Adhesion Molecules in Postmenopausal Women With Coronary Artery Disease
Caulin-Glaser T, Farrell W, Pfau S, Zaret B, Bunger K, Setaro J, Brennan J, Bender J, Cleman M, Cabin H, Remetz M. Modulation of Circulating Cellular Adhesion Molecules in Postmenopausal Women With Coronary Artery Disease. Journal Of The American College Of Cardiology 1998, 31: 1555-1560. PMID: 9626834, DOI: 10.1016/s0735-1097(98)00145-4.Peer-Reviewed Original ResearchConceptsE2 replacement therapyCoronary artery diseaseVascular cell adhesion molecule-1Cellular adhesion moleculesPostmenopausal womenAdhesion molecule-1Premenopausal womenArtery diseaseCardioprotective effectsInflammatory responseAdhesion moleculesMolecule-1Incidence of CADControl groupInflammatory cytokine-induced expressionIntercellular adhesion molecule-1Expression of CAMsCell adhesion molecule-1Consecutive eligible subjectsAssociation of estrogenEndothelial cell activationCytokine-induced expressionFemale control groupSignificant increaseEnzyme-linked immunoabsorbant assay