2001
Effect of Non–Insulin-Dependent Diabetes Mellitus on Myocardial Insulin Responsiveness in Patients With Ischemic Heart Disease
Jagasia D, Whiting J, Concato J, Pfau S, McNulty P. Effect of Non–Insulin-Dependent Diabetes Mellitus on Myocardial Insulin Responsiveness in Patients With Ischemic Heart Disease. Circulation 2001, 103: 1734-1739. PMID: 11282903, DOI: 10.1161/01.cir.103.13.1734.Peer-Reviewed Original ResearchConceptsGlucose uptakeMyocardial insulin responsivenessCoronary disease patientsCoronary blood flowDependent diabetes mellitusIschemic heart diseaseMyocardium of patientsPoor clinical outcomeNet lactate uptakeCardiac glucose uptakeFractional extractionClinical outcomesDiabetes mellitusNon-InsulinInsulin levelsInsulin resistanceCardiac responsivenessDisease patientsInsulin infusionHeart diseaseMyocardial ischemiaPeripheral tissuesGlucose levelsBlood flowArterial plasma
2000
Effect of plasma insulin level on myocardial blood flow and its mechanism of action
McNulty P, Pfau S, Deckelbaum L. Effect of plasma insulin level on myocardial blood flow and its mechanism of action. The American Journal Of Cardiology 2000, 85: 161-165. PMID: 10955370, DOI: 10.1016/s0002-9149(99)00650-5.Peer-Reviewed Original ResearchConceptsMyocardial blood flowBlood flowInsulin levelsInsulin concentrationsCoronary sinus blood flowSystemic insulin levelsVenous plasma insulinSinus blood flowMyocardial oxygen demandCoronary blood flowCoronary heart diseasePlasma insulin levelsPlasma insulin concentrationMyocardial oxygen consumptionOxidative substrate metabolismMechanism of actionCoronary toneVasoactive substancesIntracoronary infusionCoronary endotheliumCoronary circulationPlasma insulinInsulin infusionHeart diseasePhysiologic elevations