2023
PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection
Asashima H, Mohanty S, Comi M, Ruff W, Hoehn K, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, Emu B, Kleinstein S, Montgomery R, Iwasaki A, Dela Cruz C, Kaminski N, Shaw A, Hafler D, Sumida T. PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection. Cell Reports 2023, 42: 111895. PMID: 36596303, PMCID: PMC9806868, DOI: 10.1016/j.celrep.2022.111895.Peer-Reviewed Original ResearchConceptsAcute viral infectionTph cellsViral infectionCXCR3 expressionClinical outcomesHelper TSevere viral infectionsB cell helpBetter clinical outcomesProtective humoral immunityT cell-B cell interactionsKey immune responsesPlasmablast expansionB cell differentiationCell subsetsHumoral immunityCell helpImmune responseInterferon γPlasmablast differentiationB cellsPlasmablastsCell responsesInfectionCD4
2016
Single cell variability in pro-inflammatory and antiviral gene responses in dendritic cells
Fribourg Casajuana M, Hartmann B, Tabbaa O, Ramos I, Zaslavsky E, Nudelman G, Albrecht R, Merad M, Hayot F, Jayaprakash C, Kleinstein S, Garcia-Sastre A, Sealfon S. Single cell variability in pro-inflammatory and antiviral gene responses in dendritic cells. The Journal Of Immunology 2016, 196: 202.29-202.29. DOI: 10.4049/jimmunol.196.supp.202.29.Peer-Reviewed Original ResearchDendritic cellsI IFNsI interferonImmune responsePeripheral Blood Plasmacytoid Dendritic CellsBlood plasmacytoid dendritic cellsMonocyte-derived dendritic cellsType I IFNsDendritic cell populationsPlasmacytoid dendritic cellsAppropriate immune responseHuman peripheral bloodType I interferonAntiviral gene responsesRIG-I inductionH1N1 virusAutoimmune diseasesPeripheral bloodChronic infectionNoxious stimuliViral infectionImmune signalsAntiviral ISGsCell responsesISG group
2015
The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection
Dominguez C, Amezquita R, Guan T, Marshall H, Joshi N, Kleinstein S, Kaech S. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. Journal Of Cell Biology 2015, 211: 2113oia258. DOI: 10.1083/jcb.2113oia258.Peer-Reviewed Original Research