Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity
Donius LR, Cheng Y, Choi J, Sun ZY, Hanson M, Zhang M, Gierahn TM, Marquez S, Uduman M, Kleinstein SH, Irvine D, Love JC, Reinherz EL, Kim M. Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity. Journal Of Virology 2016, 90: 8875-8890. PMID: 27466419, PMCID: PMC5021391, DOI: 10.1128/jvi.01089-16.Peer-Reviewed Original ResearchConceptsMPER-specific antibodiesAntigen specificityB cellsAntigen-specific antibody responsesHIV-1 gp41 membrane-proximal external regionAmino acid sequenceBone marrow plasmaEffective preventive vaccineHIV-1 bnAbsHIV-1 cladesHIV-1 pandemicGp41 membrane-proximal external regionAnti-MPER antibodiesContext of lipidPositive selectionRegion amino acid sequencesSelective pressureAcid sequenceMembrane-proximal external regionMarrow plasmaPreventive vaccineAntibody responseBiophysical characterizationPlasma cellsVaccine formulations