Toward Quantitative Simulation of Germinal Center Dynamics: Biological and Modeling Insights from Experimental Validation
KLEINSTEIN S, SINGH J. Toward Quantitative Simulation of Germinal Center Dynamics: Biological and Modeling Insights from Experimental Validation. Journal Of Theoretical Biology 2001, 211: 253-275. PMID: 11444956, DOI: 10.1006/jtbi.2001.2344.Peer-Reviewed Original ResearchConceptsCenter dynamicsParticular mathematical modelOrdinary differential equationsGerminal center dynamicsImmune system dynamicsDifferential equationsExperimental dataMathematical modelStochastic frameworkAverage dynamicsSpecific experimental dataDeterministic modelSystem dynamicsModel parametersPossible extensionsGeneral methodologyQuantitative simulationOpreaNew implementationDynamicsModeling insightsPerelsonCenter behaviorEquationsExperimental validation