Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states
Callahan D, Smita S, Joachim S, Hoehn K, Kleinstein S, Weisel F, Chikina M, Shlomchik M. Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states. Nature Immunology 2024, 25: 562-575. PMID: 38200277, DOI: 10.1038/s41590-023-01721-9.Peer-Reviewed Original ResearchGerminal center B cellsDistinct genomic featuresDP cellsDevelopmental originsEpigenetic stateFunctional diversityEpigenetic patternsTranscriptional profilingGenomic featuresDN cellsDistinct developmental historiesB cellsReporter miceFunctional responseCellsMemory B cellsChromatinB cell subsetsCell-dependent responsesMultiple approachesProgenyDiversityT cell-dependent responsesGerminal centersDevelopmental history