2021
Sex-Biased Aging Effects on Ig Somatic Hypermutation Targeting
Cui A, Chawla DG, Kleinstein SH. Sex-Biased Aging Effects on Ig Somatic Hypermutation Targeting. The Journal Of Immunology 2021, 206: 101-108. PMID: 33288546, PMCID: PMC8582005, DOI: 10.4049/jimmunol.2000576.Peer-Reviewed Original ResearchConceptsOlder individualsDNA mismatch repair genesSex groupsObserved clinical differencesMismatch repair genesB cell IgDecreased expression levelDNA repair activityImmunologic responseClinical differencesAb responsesFemale human subjectsOld maleAged individualsImpaired levelDifferent agesYounger counterpartsPhase ILargest fold changeYoung individualsError-prone DNA repair activityExpression levelsHuman subjectsMutation patternsRepair activity
2012
Quantifying selection in high-throughput Immunoglobulin sequencing datasets (58.4)
Yaari G, Uduman M, Kleinstein S. Quantifying selection in high-throughput Immunoglobulin sequencing datasets (58.4). The Journal Of Immunology 2012, 188: 58.4-58.4. DOI: 10.4049/jimmunol.188.supp.58.4.Peer-Reviewed Original Research