2024
Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders
Dib-Hajj S, Waxman S. Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders. Journal Of Clinical Investigation 2024, 134: e182198. PMID: 38949022, PMCID: PMC11213459, DOI: 10.1172/jci182198.Peer-Reviewed Original ResearchConceptsTetrodotoxin-sensitiveHyperexcitability disordersSensory neuronsExcitability of sensory neuronsGene therapy modalitiesPeripheral sensory neuronsVoltage-gated sodiumMinimal side effectsGene therapyInduce analgesiaTherapy modalitiesSide effectsTherapeutic strategiesNav channelsAttenuating excitationIn vivoHyperexcitabilityAnalgesiaNeuronsDisordersPainTherapyGenesBiodistributionRats
1998
Resistance to anoxic injury in the dorsal columns of adult rat spinal cord following demyelination
Imaizumi T, Kocsis J, Waxman S. Resistance to anoxic injury in the dorsal columns of adult rat spinal cord following demyelination. Brain Research 1998, 779: 292-296. PMID: 9473700, DOI: 10.1016/s0006-8993(97)01171-2.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal columnsSpinal cordAction potentialsWhite matterSpinal cord dorsal columnAdult rat spinal cordAdult spinal cordRat spinal cordMin of reoxygenationAdult white matterAction potential conductionControl ratsFocal demyelinationAnoxic injurySupramaximal stimulationOnset of anoxiaAdult ratsDemyelinationPotential conductionCordX-irradiationRatsGreater recoveryOnset
1997
P-3-316 Functional repair of demyelinated spinal cordaxons in the adult rat by transplantation of genetically-engineering Schwann cells
Hommou O, Hashi K, Felts P, Waxman S, Kocsis J. P-3-316 Functional repair of demyelinated spinal cordaxons in the adult rat by transplantation of genetically-engineering Schwann cells. Clinical Neurology And Neurosurgery 1997, 99: s143. DOI: 10.1016/s0303-8467(97)81922-1.Peer-Reviewed Original Research
1995
Expression of sodium channel α- and β-subunits in the nervous system of themyelin-deficient rat
Felts P, Black J, Waxman S. Expression of sodium channel α- and β-subunits in the nervous system of themyelin-deficient rat. Brain Cell Biology 1995, 24: 654-666. PMID: 7500121, DOI: 10.1007/bf01179816.Peer-Reviewed Original ResearchConceptsSodium channel αMale littermatesSubtype-specific riboprobesDorsal root gangliaChannel αNormal male littermatesSodium channel subunitsUnaffected male littermatesDays of ageAdult expression patternRoot gangliaSpinal cordExpression patternsAdult ratsNervous systemUnaffected littermatesSodium channelsLittermatesPattern of expressionChannel subunitsRatsGreater expressionSitu hybridization techniqueUnaffected animalsPrevious reports
1986
Molecular structure of the axolemma of developing axons following altered gliogenesis in rat optic nerve
Black J, Waxman S. Molecular structure of the axolemma of developing axons following altered gliogenesis in rat optic nerve. Developmental Biology 1986, 115: 301-312. PMID: 2423398, DOI: 10.1016/0012-1606(86)90251-4.Peer-Reviewed Original ResearchConceptsRat optic nerveOptic nerveMyelinated fibersLarge caliber fibersAxonal diameterNeonatal rat optic nerveP-face IMP densityControl optic nervesDays of ageNodes of RanvierUnensheathed axonsGlial ensheathmentSystemic injectionNerveAxonsGliogenesisIMP densityAxolemmaE-face particlesCell associationIntramembranous particlesRatsOligodendrocytesMyelinEnsheathment
1985
Perinodal astrocytic processes at nodes of ranvier in developing normal and glial cell deficient rat spinal cord
Sims T, Waxman S, Black J, Gilmore S. Perinodal astrocytic processes at nodes of ranvier in developing normal and glial cell deficient rat spinal cord. Brain Research 1985, 337: 321-331. PMID: 4027576, DOI: 10.1016/0006-8993(85)90069-1.Peer-Reviewed Original ResearchConceptsPerinodal astrocytic processesLumbar spinal cordSpinal cordGlial cellsAstrocytic processesNodes of RanvierThird postnatal dayRat spinal cordSpinal cord axonsIrradiated spinal cordStages of myelinationAstrocyte involvementVentral funiculusNeuronal elementsPostnatal dayOligodendrocyte populationCentral myelinCordAstrocytesProfound reductionMyelin sheathAxonsRatsNodal axolemmaPresumptive roleDorsal-ventral differences in the glia limitans of the spinal cord: an ultrastructural study in developing normal and irradiated rats.
Sims T, Gilmore S, Waxman S, Klinge E. Dorsal-ventral differences in the glia limitans of the spinal cord: an ultrastructural study in developing normal and irradiated rats. Journal Of Neuropathology & Experimental Neurology 1985, 44: 415-29. PMID: 4009209, DOI: 10.1097/00005072-198507000-00005.Peer-Reviewed Original ResearchConceptsLumbosacral spinal cordGlia limitansDays postnatalSpinal cordSubpial astrocytesRat lumbosacral spinal cordRadial glial processesDorsal-ventral differencesDorsal funiculusNormal ratsVentral surfaceSchwann cellsPostnatal ratsRadial gliaGlial processesRatsAstrocytesCordUltrastructural studyGreater numberLimitansNormal developmentGreater degreeGliaPostnatalGlial proliferation in the irradiated rat spinal cord
Sims T, Waxman S, Gilmore S. Glial proliferation in the irradiated rat spinal cord. Acta Neuropathologica 1985, 68: 169-172. PMID: 4072625, DOI: 10.1007/bf00688641.Peer-Reviewed Original ResearchConceptsSpinal cordRat spinal cordPost-irradiation intervalsGlial proliferationIncorporation of3H-thymidineGlial cellsAdjacent thin sectionsWhite matterThick plastic sectionsCell bodiesMyelin sheathVentral halfCordOf3H-thymidineAstrogliaIrregular outlinePresent studyMitotic cellsCellsPlastic sectionsBundles of filamentsRatsMyelinationOligodendrocytes
1983
Myelin protein metabolism in demyelination and remyelination in the sciatic nerve
Smith M, Kocsis J, Waxman S. Myelin protein metabolism in demyelination and remyelination in the sciatic nerve. Brain Research 1983, 270: 37-44. PMID: 6871715, DOI: 10.1016/0006-8993(83)90789-8.Peer-Reviewed Original ResearchConceptsMyelin proteinsControl nervesLPC injectionSciatic nerveRight sciatic nerveSeries of ratsLeft nerveSchwann cellsNerveStructural myelin proteinsLPC treatmentFirst weekTime pointsAmino acid incorporationProtein metabolismLabeled amino acidsAcid incorporationMyelinDaysInjectionLysophosphatidylcholineDemyelinationRemyelinationProteinRatsFreeze-fracture ultrastructure of developing and adult non-myelinated ganglion cell axolemma in the retinal nerve fibre layer
Black J, Foster R, Waxman S. Freeze-fracture ultrastructure of developing and adult non-myelinated ganglion cell axolemma in the retinal nerve fibre layer. Brain Cell Biology 1983, 12: 201-212. PMID: 6842274, DOI: 10.1007/bf01148462.Peer-Reviewed Original ResearchConceptsRetinal nerve fiber layerNerve fiber layerNon-myelinated axonsFiber layerParticle densityMean particle diameterParticle diameterLayerNeonatal ratsElectron microscopyAdult ratsDistal segmentsParticlesConduction propertiesAdult fibersAdult animalsΜm2AxonsLow densityDensityDevelopmental ageFibersRatsHigh densityELECTROPHYSIOLOGY OF CONDUCTION IN MAMMALIAN REGENERATING NERVES11This work was supported in part by the Veterans Administration and by grants from the National Institutes of Health and the National Multiple Sclerosis Society.
Kocsis J, Waxman S. ELECTROPHYSIOLOGY OF CONDUCTION IN MAMMALIAN REGENERATING NERVES11This work was supported in part by the Veterans Administration and by grants from the National Institutes of Health and the National Multiple Sclerosis Society. 1983, 89-107. DOI: 10.1016/b978-0-12-635120-0.50010-2.Peer-Reviewed Original ResearchMyelinated axonsAction potentialsNational Multiple Sclerosis SocietyMultiple Sclerosis SocietyIntra-axonal recordingsEarly regenerating fibersNormal myelinated axonsRegenerating fibersPharmacological blockageBurst activityPotassium conductanceAxonsVeterans AdministrationNational InstituteRegenerated fibersRepolarizationFunctional organizationIonic channelsRatsAdministrationMyelin
1974
Ongoing activity in peripheral nerve: Injury discharge
Wall P, Waxman S, Basbaum A. Ongoing activity in peripheral nerve: Injury discharge. Experimental Neurology 1974, 45: 576-589. PMID: 4435078, DOI: 10.1016/0014-4886(74)90163-0.Peer-Reviewed Original Research