2005
Chapter 26 Promoting the Regeneration of Axons within the Central Nervous System
Park J, Strittmatter S. Chapter 26 Promoting the Regeneration of Axons within the Central Nervous System. 2005, 433-xviii. DOI: 10.1016/b978-012738903-5/50027-8.Peer-Reviewed Original ResearchCentral nervous systemSpinal cord injuryNervous systemPeripheral nervous system axonsPNS Schwann cellsPermanent functional deficitsRegeneration of axonsRegenerative capacityLittle functional recoveryFunctional recoveryCell transplantationCord injuryAxonal regenerationFunctional deficitsPNS neuronsCNS gliaSchwann cellsAxon regenerationCombinatorial treatmentTransplantation studiesPromising targetAxonsKinase inhibitionInjuryProteoglycan digestion
2003
Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS
Fournier AE, Takizawa BT, Strittmatter SM. Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS. Journal Of Neuroscience 2003, 23: 1416-1423. PMID: 12598630, PMCID: PMC6742251, DOI: 10.1523/jneurosci.23-04-01416.2003.Peer-Reviewed Original ResearchMeSH KeywordsADP Ribose TransferasesAmidesAnimalsAxonsBotulinum ToxinsCells, CulturedChick EmbryoEnzyme InhibitorsFemaleGanglia, SpinalIntracellular Signaling Peptides and ProteinsMotor ActivityMyelin ProteinsNerve RegenerationNeuritesNogo ProteinsPC12 CellsProtein Serine-Threonine KinasesPyridinesRatsRats, Sprague-DawleyRho GTP-Binding ProteinsRho-Associated KinasesSpinal Cord InjuriesConceptsAxonal regenerationAdult ratsNeurite outgrowthCorticospinal tract lesionsNeurite outgrowth inhibitorChick DRG neuronsRho-kinase inhibitionCST fibersDRG neuronsCST lesionLocomotor recoveryTract lesionsSpinal cordOutgrowth inhibitorInhibits neurite outgrowthNogo-66Activity levelsMyelinKinase inhibitionLesionsActivation of RhoRatsC3 transferaseInhibition of p160ROCKInhibitors