2021
Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder
Sinha R, Fogelman N, Wemm S, Angarita G, Seo D, Hermes G. Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder. Addiction Biology 2021, 27: e13116. PMID: 34856641, PMCID: PMC9872962, DOI: 10.1111/adb.13116.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional magnetic resonance imagingAlcohol use disorderAlcohol cuesHeavy drinking daysStudy 2Alcohol withdrawal symptomsNeutral visual imagesDrinking daysStudy 1 resultsUse disordersCortico-striatal dysfunctionAlcohol treatment outcomesAlcohol intakeFMRI sessionsResilient copingStriatal responsesPrefrontal cortexStudy 1Chronic alcohol useCorticostriatal dysfunctionStriatal functioningAUD patientsVisual imagesPlacebo treatment
2019
Drug-induced stress responses and addiction risk and relapse
Wemm SE, Sinha R. Drug-induced stress responses and addiction risk and relapse. Neurobiology Of Stress 2019, 10: 100148. PMID: 30937354, PMCID: PMC6430516, DOI: 10.1016/j.ynstr.2019.100148.Peer-Reviewed Original ResearchDrug useDrug-induced stress responsesAddiction riskCo-occurring drug usePeripheral stress responsesAutonomic nervous system responsesNervous system responsesDrug use historyChronic drug useChronic drug usersAdrenal axisAcute effectsEvidence of alterationsDrug usersTonic levelsGlucocorticoid responseBinge/Prefrontal cortexDifferent drugsPsychoactive drugsDrug seekingDrugsStress responseRelapseHuman research