Alcohol craving and withdrawal at treatment entry prospectively predict alcohol use outcomes during outpatient treatment
Martins JS, Fogelman N, Wemm S, Hwang S, Sinha R. Alcohol craving and withdrawal at treatment entry prospectively predict alcohol use outcomes during outpatient treatment. Drug And Alcohol Dependence 2021, 231: 109253. PMID: 34998258, PMCID: PMC8818273, DOI: 10.1016/j.drugalcdep.2021.109253.Peer-Reviewed Original ResearchConceptsAlcohol use outcomesAlcohol cravingTreatment entryDays/weekSleep difficultiesOutpatient treatmentAbstinence symptomsUse outcomesPre-treatment alcohol useEffects of cravingTreatment-seeking adultsAlcohol useAlcohol use disorder treatmentRelapse prevention counselingDrinking-related outcomesHeavy drinkingDrinking days/weekOutpatient AUD treatmentGreater alcoholChronic alcohol useDistress symptomsUse disorder treatmentAUD treatmentAverage drinksCravingAlcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder
Sinha R, Fogelman N, Wemm S, Angarita G, Seo D, Hermes G. Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder. Addiction Biology 2021, 27: e13116. PMID: 34856641, PMCID: PMC9872962, DOI: 10.1111/adb.13116.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional magnetic resonance imagingAlcohol use disorderAlcohol cuesHeavy drinking daysStudy 2Alcohol withdrawal symptomsNeutral visual imagesDrinking daysStudy 1 resultsUse disordersCortico-striatal dysfunctionAlcohol treatment outcomesAlcohol intakeFMRI sessionsResilient copingStriatal responsesPrefrontal cortexStudy 1Chronic alcohol useCorticostriatal dysfunctionStriatal functioningAUD patientsVisual imagesPlacebo treatment