2023
Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers
Wemm S, Golden M, Martins J, Fogelman N, Sinha R. Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers. Alcohol And Alcoholism 2023, 58: 653-661. PMID: 37756494, PMCID: PMC10642609, DOI: 10.1093/alcalc/agad061.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHeart rate variabilitySocial drinkersAUD groupChronic heavy alcohol useRate variabilityLife-threatening cardiovascular diseaseHRV measuresPatient-related symptomsPatient-reported symptomsHF/LF ratioSevere alcohol use disorderNervous system processesHeavy alcohol useParasympathetic dysfunctionCardiovascular diseaseHeart rate monitoringObservational studySleep difficultiesHeart rateParasympathetic activationUse disordersRSA amplitudeCardiovascular systemDays of monitoring
2021
Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder
Sinha R, Fogelman N, Wemm S, Angarita G, Seo D, Hermes G. Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder. Addiction Biology 2021, 27: e13116. PMID: 34856641, PMCID: PMC9872962, DOI: 10.1111/adb.13116.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional magnetic resonance imagingAlcohol use disorderAlcohol cuesHeavy drinking daysStudy 2Alcohol withdrawal symptomsNeutral visual imagesDrinking daysStudy 1 resultsUse disordersCortico-striatal dysfunctionAlcohol treatment outcomesAlcohol intakeFMRI sessionsResilient copingStriatal responsesPrefrontal cortexStudy 1Chronic alcohol useCorticostriatal dysfunctionStriatal functioningAUD patientsVisual imagesPlacebo treatment
2020
Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms
Sinha R, Wemm S, Fogelman N, Milivojevic V, Morgan PM, Angarita GA, Hermes G, Fox HC. Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms. American Journal Of Psychiatry 2020, 178: 447-458. PMID: 33207935, PMCID: PMC8119326, DOI: 10.1176/appi.ajp.2020.20050609.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-1 Receptor AntagonistsAdultAlcohol AbstinenceAlcoholismAnxietyCentral Nervous System DepressantsCounselingCravingDepressionDouble-Blind MethodEthanolFemaleHumansMaleMiddle AgedPrazosinProof of Concept StudySelf-Help GroupsSleep Wake DisordersSubstance Withdrawal SyndromeTreatment OutcomeConceptsAlcohol withdrawal symptomsHeavy drinking daysAlcohol use disorderDrinks/dayWithdrawal symptomsDrinking daysSecondary outcomesPrazosin efficacyAlcohol cravingSelf-reported drinking daysTreatment of AUDEfficacy of prazosinWithdrawal symptom scoresPoor treatment outcomesGlobal disease burdenCurrent alcohol dependencePrimary outcomeTreat analysisAlcohol use outcomesAlcohol intakeSymptom scoresWeek 12Prognostic indicatorDisease burdenSleep disturbancesAssociation of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation
Blaine SK, Wemm S, Fogelman N, Lacadie C, Seo D, Scheinost D, Sinha R. Association of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation. American Journal Of Psychiatry 2020, 177: 1048-1059. PMID: 32854534, PMCID: PMC7606814, DOI: 10.1176/appi.ajp.2020.19070703.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment initiationAlcohol abstinenceHeavy drinkingFunctional MRIEarly treatment outcomesEarly treatment phaseHealthy control subjectsEarly outpatient treatmentNumber of daysStress imagesDrinking outcomesChronic alcohol abuseHeavy drinking daysSignificant hyperreactivityControl subjectsOutpatient treatmentStriatal dysfunctionEarly treatmentTreatment outcomesBrain stressFunctional pathologyProspective assessmentTreatment phaseAlcohol abuse
2019
A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment
Wemm SE, Larkin C, Hermes G, Tennen H, Sinha R. A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment. Drug And Alcohol Dependence 2019, 204: 107569. PMID: 31574406, PMCID: PMC6916671, DOI: 10.1016/j.drugalcdep.2019.107569.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol intakeEarly treatmentAlcohol use disorder treatmentStressful eventsNovel treatment approachesAlcohol relapse riskUse disorder treatmentNext dayWeeks of outpatientStress-induced cravingAlcohol use outcomesRelapse riskProspective analysisUse disordersAUD patientsTreatment approachesDisorder treatmentHigher cravingDaily diariesUse outcomesIntakeAUD individualsCravingDrinking amount