2014
The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium
Ahmadi A, McNeill B, Vulesevic B, Kordos M, Mesana L, Thorn S, Renaud JM, Manthorp E, Kuraitis D, Toeg H, Mesana TG, Davis DR, Beanlands RS, DaSilva JN, deKemp RA, Ruel M, Suuronen EJ. The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium. Biomaterials 2014, 35: 4749-4758. PMID: 24631247, DOI: 10.1016/j.biomaterials.2014.02.028.Peer-Reviewed Original ResearchConceptsMatrix therapyMouse myocardial infarction modelMyocardial infarction modelCardiac cell therapySynergistic therapeutic effectTherapeutic effectMyocardial perfusionParacrine propertiesInfarcted myocardiumAngiogenic cellsInfarction modelOverall efficacyTherapyCell therapyAngiogenic potentialCACSΑ5 integrinIntegrin α2EngraftmentIntegrin α5PerfusionCellsIntegrinsCollagen matrixCAC function
2013
Preclinical Evaluation of Biopolymer-Delivered Circulating Angiogenic Cells in a Swine Model of Hibernating Myocardium
Giordano C, Thorn SL, Renaud JM, Al-Atassi T, Boodhwani M, Klein R, Kuraitis D, Dwivedi G, Zhang P, DaSilva JN, Ascah KJ, deKemp RA, Suuronen EJ, Beanlands RS, Ruel M. Preclinical Evaluation of Biopolymer-Delivered Circulating Angiogenic Cells in a Swine Model of Hibernating Myocardium. Circulation Cardiovascular Imaging 2013, 6: 982-991. PMID: 24089461, DOI: 10.1161/circimaging.113.000185.Peer-Reviewed Original ResearchConceptsMyocardial blood flowHibernating myocardiumAngiogenic cellsBlood flowSwine modelAdvanced coronary artery diseaseLeft circumflex artery territoryRelevant swine modelCoronary artery diseaseCircumflex artery territoryLeft circumflex arteryCirculating Angiogenic CellsWall motion abnormalitiesMyocardial flow reserveArtery territoryUnderwent placementArtery diseaseEjection fractionCircumflex arteryCell-based therapiesRevascularization approachTomography perfusionMyocardial hibernationAmeroid constrictorPreclinical swine model