2019
Limited indirect effects of an infant pneumococcal vaccination program in an aging population
van der Linden M, Imöhl M, Perniciaro S. Limited indirect effects of an infant pneumococcal vaccination program in an aging population. PLOS ONE 2019, 14: e0220453. PMID: 31369597, PMCID: PMC6675109, DOI: 10.1371/journal.pone.0220453.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseSerotype 3 invasive pneumococcal diseaseHerd protection effectsIPD casesAge groupsPCV13-type invasive pneumococcal diseaseAdult invasive pneumococcal diseaseAdult pneumococcal vaccinationPneumococcal vaccination programAdults 60 yearsVaccine serotypes 4Years of ageAdult age groupsIndirect protection effectPneumococcal vaccinationPneumococcal diseasePolysaccharide vaccineVaccine recommendationsChildhood vaccinationVaccination programVaccine formulationsAdult coverageAdults 60Protection effectSerotype 4Regional variations in serotype distribution and vaccination status in children under six years of age with invasive pneumococcal disease in Germany
Perniciaro S, Imöhl M, Fitzner C, van der Linden M. Regional variations in serotype distribution and vaccination status in children under six years of age with invasive pneumococcal disease in Germany. PLOS ONE 2019, 14: e0210278. PMID: 30625215, PMCID: PMC6326516, DOI: 10.1371/journal.pone.0210278.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseVaccine-type invasive pneumococcal diseaseVT invasive pneumococcal diseaseUnvaccinated childrenSerotype distributionPneumococcal diseaseVaccination statusHigher oddsChildhood invasive pneumococcal diseaseDifferent serotype distributionSerotype of infectionVaccine-type serotypesNon-vaccine serotypesDose of vaccineYears of agePCV10 groupPCV13 groupPCV7 groupVaccine recommendationsAdministration scheduleContinued surveillanceProtective effectParticular serotypeInfectionSignificant predictors
2015
Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany
Imöhl M, Möller J, Reinert R, Perniciaro S, van der Linden M, Aktas O. Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany. BMC Infectious Diseases 2015, 15: 61. PMID: 25885764, PMCID: PMC4335684, DOI: 10.1186/s12879-015-0787-1.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseMeningitis casesPneumococcal meningitisQuellung reactionGerman National Reference CenterNeufeld Quellung reactionPre-PCV7 periodPneumococcal conjugate vaccinePost-vaccination periodCase mortality rateNational Reference CenterAntibiotic nonsusceptibilityIPD isolatesPneumococcal diseaseVaccination recommendationsVaccine recommendationsConjugate vaccineVaccine serotypesBroth microdilution methodVaccine effectsNationwide surveillancePneumococcal isolatesSerotype prevalenceReference centerMortality rate