2022
Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats
Villiamma P, Casby J, Groman SM. Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. Psychopharmacology 2022, 239: 2885-2901. PMID: 35705734, PMCID: PMC10332493, DOI: 10.1007/s00213-022-06174-w.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AddictiveCocaineDecision MakingFemaleMaleRatsRats, Long-EvansReinforcement, PsychologyReversal LearningRewardConceptsCocaine-taking behaviorReversal-learning performanceDecision-making functionsReversal-learning taskReinforcement learning modelIndividual differencesAdolescent developmentFemale Long-Evans ratsRewarded outcomesDevelopmental trajectoriesNeurobiological mechanismsAdolescent trajectoriesAge-related changesGreater cocaineBiobehavioral mechanismsNeural adaptationLong-Evans ratsPredictive relationshipAddiction susceptibilityAdolescenceChoice behaviorAdulthoodDecision-making trajectoriesMental illnessChoice data
2020
Reinforcement Learning during Adolescence in Rats
Afshar N, Keip AJ, Taylor JR, Lee D, Groman SM. Reinforcement Learning during Adolescence in Rats. Journal Of Neuroscience 2020, 40: 5857-5870. PMID: 32601244, PMCID: PMC7380962, DOI: 10.1523/jneurosci.0910-20.2020.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsConditioning, OperantFemaleHumansMaleRatsRats, Long-EvansReinforcement, PsychologyReversal LearningConceptsNovel behavioral protocolReversal-learning performanceAdaptive choice behaviorBehavioral protocolFemale Long-Evans ratsReversal performanceChoice behaviorLong-Evans ratsAdolescent brain functionAge-related improvementsReinforcement-learning mechanismsReversal-learning taskReversal-learning paradigmDecision-making paradigmReinforcement learning mechanismAdolescent ratsLongitudinal designAge-related changesNeurodevelopmental mechanismsAdolescencePositive outcomesBrain functionFunction of circuitsPostnatal day 30AdulthoodParanoia as a deficit in non-social belief updating
Reed EJ, Uddenberg S, Suthaharan P, Mathys C, Taylor JR, Groman SM, Corlett PR. Paranoia as a deficit in non-social belief updating. ELife 2020, 9: e56345. PMID: 32452769, PMCID: PMC7326495, DOI: 10.7554/elife.56345.Peer-Reviewed Original ResearchConceptsParanoid individualsSocial threatLearning differencesTask environmentLearning behaviorOnline participantsMethamphetamine exposureParanoiaBeliefsVolatile environmentMental illnessComputational modelingIndividualsElevated sensitivityDeficitsAnticipationParticipantsParadigmThreatMethamphetamineDifferencesFurther assessmentBehaviorHarm
2018
Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task
Groman SM, Massi B, Mathias SR, Curry DW, Lee D, Taylor JR. Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task. Journal Of Neuroscience 2018, 39: 295-306. PMID: 30413646, PMCID: PMC6325257, DOI: 10.1523/jneurosci.2219-18.2018.Peer-Reviewed Original ResearchConceptsMultistage taskBehavioral platformDopamine toneDecision Making TaskValue-based choiceDecision-making taskNovel behavioral paradigmModel-based learningConsequences of actionsReinforcement learning systemNeuroscience studiesBehavioral paradigmsBiobehavioral mechanismsVentral striatumNeurobehavioral levelBehavioral dissectionNovel analytic approachCortex correlatesRetrospective appraisalChoice behaviorTaskBehavioral mechanismsMental disordersModel-based systemLearning
2017
Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats
Groman SM, Rich KM, Smith NJ, Lee D, Taylor JR. Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats. Neuropsychopharmacology 2017, 43: 770-780. PMID: 28741627, PMCID: PMC5809784, DOI: 10.1038/npp.2017.159.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzazepinesCentral Nervous System StimulantsDecision MakingMaleMethamphetamineRatsRats, Long-EvansReinforcement, PsychologyConceptsReinforcement learning processAbility of ratsNegative outcomesAdaptive decision-making strategiesProbabilistic reversal learningStimulus-reward contingenciesDopamine D2/3 receptor antagonistDynamic decision makingMaladaptive decisionReversal learningDecision-making strategiesD2/3 receptor antagonistOutcome behaviorsPsychostimulant methamphetamineChronic exposurePsychostimulant addictionChoice behaviorBehavioral mechanismsComputational modelDetrimental outcomesPsychostimulant drugsCurrent studyDecision makingDecision-making processDrug use
2016
Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making
Groman SM, Smith NJ, Petrullli JR, Massi B, Chen L, Ropchan J, Huang Y, Lee D, Morris ED, Taylor JR. Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making. Journal Of Neuroscience 2016, 36: 6732-6741. PMID: 27335404, PMCID: PMC4916249, DOI: 10.1523/jneurosci.3253-15.2016.Peer-Reviewed Original ResearchConceptsD3 receptor availabilityCorticostriatal brain regionsReversal-learning taskGoal-directed behaviorFlexible decision makingAbility of ratsReceptor availabilityFlexible adaptive behaviorDecision-making behaviorLearning rateIndividual differencesProbabilistic reinforcementReversal taskInitial learningProbabilistic discriminationReversal performanceDecision-making processCombined neuroimagingFlexible behaviorAdaptive behaviorComputational modelingReversal phaseSpatial acquisitionBrain regionsD3-preferring agonists
2010
Behavioral Characteristics and Neural Mechanisms Mediating Performance in a Rodent Version of the Balloon Analog Risk Task
Jentsch JD, Woods JA, Groman SM, Seu E. Behavioral Characteristics and Neural Mechanisms Mediating Performance in a Rodent Version of the Balloon Analog Risk Task. Neuropsychopharmacology 2010, 35: 1797-1806. PMID: 20375994, PMCID: PMC3055471, DOI: 10.1038/npp.2010.47.Peer-Reviewed Original ResearchConceptsBalloon Analogue Risk TaskRisk TaskPotential food rewardsMedial prefrontal cortexBiomarker of vulnerabilityRodent versionRisk-taking behaviorNeural basisIncentive motivationSuboptimal respondingFood rewardOrbitofrontal cortexPrefrontal cortexNeural circuitryHigh risk takingRewardGreater rewardsSubset of ratsLaboratory measuresFood pelletsHigh-risk behaviorsBehavioral characteristicsTaskCortexGreat public health concern