All roads lead to IgA: Mapping the many pathways of IgA induction in the gut
Siniscalco E, Williams A, Eisenbarth S. All roads lead to IgA: Mapping the many pathways of IgA induction in the gut. Immunological Reviews 2024 PMID: 39046160, DOI: 10.1111/imr.13369.Peer-Reviewed Original ResearchIgA inductionFood allergyFood-specific IgE.Food-specific IgEAntibody isotypesPrevalence of food allergyT cell helpIncreasing prevalence of food allergyRelease of histamineFoodFood antigensB cellsInduce toleranceAdverse reactionsCommensal bacteriaMast cellsIncreased prevalenceGut immunityIgAGutAllergyAntibodiesIsotypeInductionDendritic Cells in Food Allergy, Treatment, and Tolerance
Liu E, Yin X, Siniscalco E, Eisenbarth S. Dendritic Cells in Food Allergy, Treatment, and Tolerance. Journal Of Allergy And Clinical Immunology 2024 PMID: 38971539, DOI: 10.1016/j.jaci.2024.06.017.Peer-Reviewed Original ResearchAntigen presenting cellsDendritic cellsFood allergyOral tolerancePresenting cellsAllergic sensitizationPeripheral T regulatory cellsDevelopment of oral toleranceGut dendritic cellsT regulatory cellsDendritic cell subsetsLimited treatment optionsAdaptive immune responsesFood immunotherapyEpicutaneous immunotherapyCell subsetsTolerogenic programAlarmin releaseTreatment optionsLangerhans cellsFood toleranceInnocuous antigensSurface markersInflammatory conditionsImmune responseNovel and emerging tests for food allergy
Liu E, Eisenbarth S. Novel and emerging tests for food allergy. 2024, 698-709. DOI: 10.1016/b978-0-323-96018-2.00081-x.Peer-Reviewed Original ResearchFood allergyActivation testingSkin prick testingRisk of developmentAvailable clinical testsSkin barrier permeabilityLow predictive valueInflammatory markersPrick testingIgE testingImmunoglobulin EBarrier permeabilityAllergyPromising biomarkerPredictive valueClinical testsGenetic testingLack of testingCellular profilingMarkersWidespread useTestingImmunoglobulinBiomarkersSeverity